Abstract
A multiple behavioral schedule with food reinforcement was designed to measure the drug-induced performance enhancement and non-effective activity in rats. The schedule, 20 min in duration, had CRF components in the 33 trials and extinction components in the inter-trial periods. During each trial, food reinforcement was present in the limited period (8 sec each) which was preceded by a discriminative stimulus (1 sec, either a light or a footshock). The rats generated a high rate of lever pressing during the limited period and a low rate of lever pressing during the inter-trial period. The drugs studied were d-amphetamine, methylphenidate, pipradrol and phenindamine. At low dosages, these drugs increased further the high rate of lever pressing. This was considered to be the performance enhancement effect. At higher doses, the drugs increased the low rate of lever pressing, decreased the high rate of lever pressing, and decreased responding of the rats to the discriminative stimulus. This latter pattern was considered to be the non-effective activity caused by the drugs. As expected, d-amphetamine was the most potent. Minor differences in drug effects were seen between the group of rats having light and that group having footshock as discriminative stimulus.
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Brown, B. B., Werner, H. W.: Pharmacologic studies on a new central stimulant, α-(2-piperidyl) benzhydrol hydrochloride (MRD-108). J. Pharmacol. exp. Ther. 110, 180–187 (1954)
Clark, F. C., Steele, B. J.: Effects of d-amphetamine on performance under a multiple schedule in the rat. Psychopharmacologia (Berl.) 9, 157–169 (1966)
Dews, P. B.: Studies on behavior. IV. Stimulant actions of methamphetamine. J. Pharmacol. exp. Ther. 122, 137–147 (1958)
Dews, P. B., Morse, W. H.: Behavioral pharmacology. Ann. Rev. Pharmacol. 1, 145–174 (1961)
Frank, R.: Study of a new histamine antagonist. (2-Methyl-9-phenyl-2,3,4,9-tetrahydro-1-pyridindene hydrogen tartrate.) Ann. Allergy 48, 398–404 (1948)
Froelich, R. E., Heckel, R. V.: The psychological effects of methylphenidate. J. clin. exp. Psychopath. 23, 91–98 (1962)
Innes, I. R., Nickerson, M.: Drugs acting on postganglionic adrenergic nerve endings and structures innervated by them (Sympathomimetic drugs). In: The pharmacological basis of therapeutics, 3rd. Ed., L. S. Gooman and A. Gilman, eds., pp. 477–520. New York: Macmillan 1965
Kelleher, R. T., Morse, W. H.: Determinants of the specificity of behavioral effects of drugs. Ergebn. Physiol. 60, 1–56 (1968)
Laties, V. G.: The modification of drug effects on behavior by external discriminative stimuli. J. Pharmacol. exp. Ther. 183, 1–13 (1972)
Laties, V. G., Weiss, B.: Performance enhancement by the amphetamines: A new appraisal. In: Proceedings, Vth International Congress of the Collegium Internationale Neuro-Psychopharmacologium, Washington, 1966, by H. Brill, J. O. Cole, P. Deniker, H. Hippius, and P. B. Bradley, eds., pp. 800–808, ICS 129. Amsterdam: Excerpta Medica 1967
Leake, C. D.: The amphetamines. Their action and uses. Springfield, Ill.: Ch. C. Thomas 1958
Lehmann, G.: Pharmacological properties of a new antihistaminic, 2-methyl-9-phenyl-2,3,4,9-tetrahydro-1-pyridindene (Thephorin) and derivatives. J. Pharmacol. exp. Ther. 92, 249–259 (1948)
Lehmann, G., Randall, L. O., Hagan, E.: The anti-histamine, anti-adrenaline and anti-acetylcholine action of Thephorin. Arch. int. Pharmacodyn. 78, 253–267 (1949)
McGavack, T. H., Weissberg, J., Shearman, A., Fuchs, A. M., Schulman, P. M., Drekter, I. J., Boyd, L. J.: Clinical evaluation of phenindamine (2-methyl-9-phenyl-2,3,4,9-tetrahydro-1-pyridindene hydrogen tartrate) as an antihistaminic agent. Amer. J. med. Sci. 216, 437–445 (1948)
McMillan, D. E.: Effects of d-amphetamine on performance under several parameters of multiple fixed-ratio, fixedinterval schedules. J. Pharmacol. exp. Ther. 167, 26–33 (1969)
Meier, R., Gross, F., Tripod, J.: Ritaline, eine neuartige synthetische Verbindung mit spezifischer zentralerregender Wirkungskomponente. Klin. Wschr. 32, 445–450 (1954)
Payne, R. B., Moore, E. W.: The effects of some analeptic and depressant drugs upon tracking behavior. J. Pharmacol. exp. Ther. 115, 480–484 (1955)
Pennypacker, C. S., Sharpless, I.: Clinical study of a new antihistaminic drug-Thephorin. Penn. med. J. 51, 1407–1411 (1948)
Weiss, B., Laties, V. G.: Enhancement of human performance by caffeine and the amphetamines. Pharmacol. Rev. 14, 1–36 (1962)
Weiss, B., Laties, V. G.: Reconciling the effects of amphetamine on human and animal behavior. Proc. Europ. Soc. Study Drug Toxicity 12, 32–36 (1971)
Winter, C. A., Flataker, L.: The effect of antihistaminic drugs upon the performance of trained rats. J. Pharmacol. exp. Ther. 101, 156–162 (1951)
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Submitted to the Stanford University by T. O. T. Ts'o in partial fulfillment of the requirements for the Ph.D. degree.
This work was supported by Grants of the United States Public Health Service-GM322, MH03374, and MH03241.
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Ts'o, T.O.T., Hance, A.J. & Killam, K.F. Performance enhancement effects of d-amphetamine, methylphenidate, pipradrol and phenindamine in rats. Psychopharmacologia 46, 65–72 (1976). https://doi.org/10.1007/BF00421551
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DOI: https://doi.org/10.1007/BF00421551