Abstract
State-Dependent Learning (SDL) occurs when a response learned in a particular drug state does not transfer to another drug state. SDL was demonstrated and disrupted in a modified T-maze escape learning task, using male hooded rats. SDL groups were trained each day in one drug state (either Librium, 40 mg/kg or sterile water) and then given non-shock test trials in both drug states. SDL Ss showed drug-dependent retention since they turned randomly in opposite-state test trials and significantly above random level (P<0.02) when in the training drug state. For the Transfer Ss, a 1 kHz tone was simultaneously paired with foot shock in training, and continued to be sounded on every non-shock test trial. Transfer Ss turned in the training direction regardless of drug state. Drug-dependence in the SDL groups and transfer in the Transfer groups were also demonstrated in response latencies. The tones were emotional memory prompters initiating some process that mediated transfer between drug states. The theoretical importance of these results were discussed in relation to energizing and directing functions of emotions and symmetrical and asymmetrical transfer.
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References
Bindra, D., Nyman, K., Wise, J.: Barbiturate-induced dissociation of acquisition and extinction: role of movement-initiating processes. J. comp. physiol. Psychol. 60, 223–228 (1965)
Bindra, D., Reichert, H.: Dissociation of movement initiation without dissociation of response choice. Psychonom. Sci. 4, 95–96 (1966)
Connelly, J. F., Connelly, J. M., Epps, J. O.: Disruption of dissociated learning in a discrimination paradigm by emotionally-important stimuli. Psychopharmacologia (Berl.) 30, 275–285 (1973)
Dixon, W. J., Massey, F. J., Jr.: Introduction to statistical analysis. New York: McGraw-Hill 1968
Hill, H. E., Jones, B. E., Bell, E. C.: State dependent control of discrimination by morphine and pentobarbital. Psychopharmacologia (Berl.) 22, 305–313 (1971)
Holloway, F. A.: State-dependent effects of Ethanol on active and passive avoidance learning. Psychopharmacologia (Berl.) 25, 238–261 (1972)
Holloway, F. A., Wansley, R. A.: Motivational parameters in ethanol-induced state-dependent dissociation of avoidance learning. Physiol. Psychol. 2, 71–74 (1974)
Iawahara, S., Matsushita, K.: Effects of drug-state changes upon black-white discrimination learning in rats. Psychopharmacologia (Berl.) 19, 347–358 (1971)
Overton, D. A.: State-dependent or “dissociated” learning produced with pentobarbital. J. comp. physiol. Psychol. 57, 3–12 (1964)
Overton, D. A.: Dissociated learning in drug states (statedependent learning). In: Psychopharmacology: A review of progress 1957–1967. Department of Health, Education and Welfare (1967)
Overton, D. A.: Discriminative control of behavior by drug states. In: Stimulus property of drugs, Thompson and Pickens (eds.). New York: Appleton-Century-Crofts 1971
Sachs, E., Weingarten, M., Klein, N. W., Jr.: Effects of chlordiazepoxide on the acquisition of avoidance learning and its transfer to the normal state and other drug conditions. Psychopharmacologia (Berl.) 9, 17–30 (1966)
Winer, B. J.: Statistical principles in experimental design. New York: McGraw-Hill 1971
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Connelly, J.F., Connelly, J.M. & Phifer, R. Disruption of State-Dependent learning (memory retrieval) by emotionally-important stimuli. Psychopharmacologia 41, 139–143 (1975). https://doi.org/10.1007/BF00421071
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DOI: https://doi.org/10.1007/BF00421071