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Wirkungen von Psychopharmaka auf das Explorationsverhalten von MÄusen

Effects of psychotropic drugs on exploratory behavior of mice

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Abstract

  1. 1.

    Locomotion (number of crossed squares) in an open field-situation and exploration (number of explored holes) in a planche à trous situation have been determined in mice naive to the experimental situation.

  2. 2.

    The sedative properties of chlorpromazine, haloperidol, and reserpine were represented by a simultaneous decrease of exploration and locomotion.

  3. 3.

    Chlordiazepoxide, oxazepam, and diazepam in low doses caused an increase of locomotion, in higher doses a decrease of exploration, and finally an inhibition of both types of behavior.

  4. 4.

    After phenobarbital the locomotion and exploration of the animals was considerably increased.

  5. 5.

    Amphetamine caused a significant inhibition of exploration in low doses which did not increase locomotion. When locomotion was enhanced the exploration still remained depressed.

  6. 6.

    Imipramine in large doses caused a decrease of both locomotion and exploration. No equivalents could be found for the antidepressant properties of the drug.

  7. 7.

    Mescaline caused an increase of locomotion and a decrease of exploration, but only in a dose range which has to be considered neurotoxic.

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Authors and Affiliations

  1. Pharmakologische Abteilung, C. H. Boehringer Sohn, Ingelheim am Rhein, Bundesrepublik Deutschland

    K. Minck, P. Danneberg & F. Knappen

  2. c/o Fa. E. Merck, D-6100, Darmstadt, Frankfurter Stra\e 250, Bundesrepublik Deutschland

    K. Minck

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  1. K. Minck
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  2. P. Danneberg
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  3. F. Knappen
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Für die sorgfÄltige Durchführung der Versuche haben wir FrÄulein A. Sondhau\ sehr zu danken.

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Minck, K., Danneberg, P. & Knappen, F. Wirkungen von Psychopharmaka auf das Explorationsverhalten von MÄusen. Psychopharmacologia 39, 245–257 (1974). https://doi.org/10.1007/BF00421032

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  • DOI: https://doi.org/10.1007/BF00421032

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