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Influence of nicotinic acid and pentaerythritoltetranicotinate (Perycit®, Bofors) on the cardiac output in man

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Summary

The effect of nicotinic acid and pentaerythritoltetranicotinate (Perycit®, Bofors) on cardiac output, FFA-level and content of free nicotinic acid in plasma was studied in healthy humans —. Nicotinic acid infused intravenously in a dose of 0.05 mg/kg/min for 180 min or administered orally in a dose of 1 g increased the cardiac output maximally by about 20 per cent for 30–60 min. The total peripheral resistance decreased and the pulse rate and stroke volume increased moderately. Pentaerythritoltetranicotinate produced the same effects but the increase of cardiac output lasted longer. In all series there was a considerable decrease of the FFA-level of plasma. The increase of the plasma concentration of nicotinic acid was most pronounced after 1 g of nicotinic acid administered orally. The effect on the cardiac output was greatest the longer the plasma concentration of nicotinic acid increased.

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Authors and Affiliations

  1. The University Lung Clinic, Renströmska Sjukhuset, S-402 60, Göteborg 17, Sweden

    Barbro Ekström-Jodal, Lennart Harthon, Egil Häggendal, Rolf Malmberg & Nils Svedmyr

  2. Department of Clinical Physiology and the Department of Anesthesiology II, Sahlgrenska Sjukhuset, University of Göteborg, Sweden

    Barbro Ekström-Jodal, Lennart Harthon, Egil Häggendal, Rolf Malmberg & Nils Svedmyr

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  1. Barbro Ekström-Jodal
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  2. Lennart Harthon
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  3. Egil Häggendal
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  4. Rolf Malmberg
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  5. Nils Svedmyr
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Ekström-Jodal, B., Harthon, L., Häggendal, E. et al. Influence of nicotinic acid and pentaerythritoltetranicotinate (Perycit®, Bofors) on the cardiac output in man. Pharmacol. Clin. 2, 86–89 (1970). https://doi.org/10.1007/BF00420712

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  • DOI: https://doi.org/10.1007/BF00420712

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