Summary
Glucagon-like peptide-1 (GLP-1) is a hormone derived from the preproglucagon molecule that is secreted by intestinal L cells and stimulates insulin secretion from betacells. The GLP-1 receptor is a candidate gene for diabetes mellitus, as mutations may induce the impaired insulin response that is a characteristic feature of NIDDM. To study the relationship between the GLP-1 receptor gene and NIDDM, linkage of a microsatellite polymorphism flanking the GLP-1 receptor gene with diabetes was investigated in three Caucasian families with MODY and in the nuclear families of 12 NIDDM probands. A cumulative LOD score −8.50 excludes linkage in these MODY pedigrees. A LOD score of −1.24 in the NIDDM nuclear pedigrees makes linkage improbable. Mutations in or near the GLP-1 receptor gene are unlikely to be the major cause of the inherited predisposition to NIDDM in Caucasian pedigrees, but we cannot exclude a role for this locus in a polygenic model or a major role in some pedigrees.
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Abbreviations
- GLP-1:
-
Glucagon-like peptide-1
- NIDDM:
-
noninsulin-dependent diabetes mellitus
- MODY:
-
maturity onset diabetes of the young
- LOD:
-
logarithm of the odds for linkage vs non-linkage
- IGT:
-
impaired glucose tolerance
- bp:
-
base pair
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Zhang, Y., Cook, J.T.E., Hattersley, A.T. et al. Non-linkage of the glucagon-like peptide 1 receptor gene with maturity onset diabetes of the young. Diabetologia 37, 721–724 (1994). https://doi.org/10.1007/BF00417698
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DOI: https://doi.org/10.1007/BF00417698