Abstract
Recently, several genes that predispose to type 2 diabetes have been discovered. There is ample evidence to indicateĀ a genetic predisposition to the microvascular complication of nephropathy in people with both type 1 and type 2 diabetes, in addition to the well-known and potent effects of environmental variables. In populations all over the world, familial aggregation of phenotypes such as end-stage renal disease, albuminuria, and chronic kidney disease has frequently been recorded. Heritability estimations for albuminuria and glomerular filtration rate also show considerable influences from inherited variables. Recent genome-wide linkage analyses have examined positional candidate genes under numerous chromosomal areas that are more likely to contain genes that increase the risk of developing diabetic nephropathy. The hereditary elements of diabetic kidney disease are reviewed in this book chapter, with a focus on recently identified genes and pathways. It appears likely that inheriting risk alleles at numerous susceptibility loci, in the presence of hyperglycemia, increases the risk for diabetes-associated kidney damage. In contrast to the molecular genetic studies, which have already been fully reviewed elsewhere, this book chapter focuses on the gathered data on hereditary factors from family studies in order to assess the role of genetic vulnerability in diabetic nephropathy.
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Kulanthaivel, L., Ganesan, G., Kirubhanand, C., Subbaraj, G.K. (2023). Diabetic and Nephropathy. In: Noor, R. (eds) Advances in Diabetes Research and Management. Springer, Singapore. https://doi.org/10.1007/978-981-19-0027-3_5
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