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Immunopathology of psoriasis

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Summary

Immunofluorescence (IF) studies by the direct and indirect methods demonstrate immunoglobulins and complement bound in vivo in psoriatic scales. The IF pattern is comparable to that of stratum corneum antibodies (SCAb) bound in vitro on specific substrate, as visualized by the indirect IF method. Formation of immune complexes can be responsible for the “squirting papilla” phenomenon, and conversion of the stratum corneum — which is normally an inaccessible antigen — into its reactive form seems to be brought about by proteases of polymorphonuclear leukocytes. Stimulation of protease production by polymorphonuclears appears to be an important factor in the pathogenesis of psoriasis. The stratum corneum of the epidermis is probably the target, and becomes an antigen for SCAb present in the circulation.

Zusammenfassung

Untersuchungen der psoriatischen Hautveränderungen mittels der direkten und indirekten Immunofluorescenzmethode zeigen in der Hornschicht Immunoglobulin- und Komplementablagerungen auf. Das IF-Muster ist dasselbe wie bei der Bindung der im normalen Serum auftretenden anti-Stratum corneum-Antikörper an dem spezifischen Substrat, d.h. normaler Hornschicht. Die Bildung von Immunkomplexen zusammengesetzt von anti-Stratum corneum-Antikörpern scheint das Phänomen der «Squirting papilla» zu verursachen, wobei das normalerweise nicht zugängliche Stratum corneum unter der Einwirkung von Traumen oder Leukocyten-Proteinasen antigenisch wird. Die Proteinase-Produktion durch angeregte polymorphonukleare Leukocyten ist vermutlich ein wichtiger pathogenetischer Faktor in Psoriasis, wobei das Stratum corneum das Target ihrer Einwirkung ist und reaktiv (antigenisch) wird, was die in vivo-Fixation der Stratum corneum-Antikörper ermöglicht.

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References

  1. Beutner, E. H., Jabłońska, S., Jarzabek-Chorzelska, M., Maciejowska, E., Rzęsa, G., Chorzelski, T. P.: Studies in immunodermatology. VI. IF studies of autoantibodies to the stratum corneum and of in vivo fixed IgG in stratum corneum of psoriatic scales. Int. Arch. Allergy 48, 301–323 (1975)

    Article  CAS  PubMed  Google Scholar 

  2. Beutner, E. H., Chorzelski, T. P., Jabłońska, S.: Autoimmunity in psoriasis. I. Studies on the possible significance of the universal stratum corneum antibodies in the pathogenesis of psoriasis. In Psoriasis, Farber, E. M., Cox, A. J., Jacobs, P. H., Nall, M. L., (eds.), pp. 63–72 New York, N.Y.: Yorke Medical Books (1977)

    Google Scholar 

  3. Beutner, E. H., Jarz cabek-Chorzelska, M., Jabłońska, S., Chorzelski, T. P., Rzęsa, G.: Autoimmunity in psoriasis. A complement immunofluorescence study. Arch. Dermatol. Res. 261, 123–134 (1978a)

    Article  CAS  PubMed  Google Scholar 

  4. Beutner, E. H., Chorzelski, T. P., Binder, W. L.: Nature of autoimmunity: pathologic versus physiologic responses and a unifying concept-in Immunopathology of the skin, Beutner, E. H., Chorzelski, T. P., Bean, S. F., (eds.). New York, N.Y.: Publ. I. Wiley and Sons, 1978b

    Google Scholar 

  5. Beutner, E. H., Jabłońska, S., Chorzelski, T. P., Binder, W. L.: Nature of autoimmunity and of SCAg conversion. International Convocation of Immunology Proceedings Niagara Falls 1978, (ed.) Milgrom, F. Basel: A. Karger 1978c

    Google Scholar 

  6. Binder, W. L.: Titers of stratum corneum antibodies and rheumatoid factor eluted from scales of a patient with psoriatic arthritis (part of the Thesis), 1978, Suny, Buffalo, N.Y.

    Google Scholar 

  7. Braun-Falco, O., Christophers, E.: Structural aspects of initial psoriatic lesions. Arch. Dermatol. Forsch., 251, 95–110 (1974)

    Article  CAS  PubMed  Google Scholar 

  8. Braun-Falco, O., Maciejewski, W., Schmoeckel, Ch., Scherer, R.: Immunoelectronmicroscopical demonstration of in vivo bound complement C3 in psoriatic lesions. Arch. Dermatol. Res., 260, 57–62 (1977a)

    Article  CAS  PubMed  Google Scholar 

  9. Braun-Falco, O.: The initial psoriatic lesions in psoriasis, Proceedings of the Second International Symposium, Stanford 1976, (ed.) Farber, E. M., Cox, A. J. pp. 1–11. New York: Publ. Yorke Medical Books 1977b

    Google Scholar 

  10. Braun-Falco, O., Männel, Ch., Scherer, R.: Nachweis von zirkulierenden löslichen Immunkomplexen im Serum von Psoriasis Patienten mit dem 125J-C1 Q-Test. Hautarzt 28, 658–660 (1977c)

    CAS  PubMed  Google Scholar 

  11. Braun-Falco, O., Schmoeckel, Ch.: The dermal inflammatory reaction in initial psoriatic lesions. Arch. Dermatol. Res. 258, 9–11 (1977d)

    Article  CAS  PubMed  Google Scholar 

  12. Christophers, E., Parzefall, R., Braun-Falco, O.: Initial events in psoriasis: quantitative assessment. Br. J. Dermatol. 89, 327–334 (1973)

    Article  CAS  PubMed  Google Scholar 

  13. Chowaniec, O.: Clinical and histological studies on the development of psoriatic popules. (Thesis — in Polish) 1978

  14. Cormane, R. H., Hunyadi, J., Hamerlinck, F.: Immungenetische Aspekte der Pathogenese der Psoriasis. Dermatol. Mschr. 163, 885–899 (1977)

    CAS  Google Scholar 

  15. Florin-Christensen, A., Maldonado Cocco, J. A., Arana, R., Porrini, A., Mom, A., Garcia Morteo, O.: Anti-γ-globulin factors in psoriasis. Dermatologica 149, 220–224 (1974)

    Article  CAS  PubMed  Google Scholar 

  16. Fyrand, O., Mellbye, O. J., Natvig, J. B.: Immunofluorescence studies for immunoglobulins and complement C3 in synovial joint membranes in psoriatic arthritis. Clin. Exp. Immunol. 29, 422–427 (1977)

    CAS  PubMed  PubMed Central  Google Scholar 

  17. Gliński, W., Obałek, S., Langner, A., Jabłońska, S., Haftek, M.: Defective function of T lymphocytes in psoriasis. J. Invest. Dermatol 70, 105–110 (1978a)

    Article  PubMed  Google Scholar 

  18. Gliński, W., Haftek, M., Obałek, S., Sochor, H.: Immunological abnormalities in psoriasis: the inhibition of leucocyte migration by stratum corneum antigens. Dermatologica 156, 231–237 (1978b)

    PubMed  Google Scholar 

  19. Guilhou, J. J., Clot, J., Meynadier, J., Charmasson, E., Brochien, J., Rimbaud, P.: Déficit des T-lymphocytes dans le psoriasis. Ann. Dermatol. Syphiligr. (Paris) 103, 58–583 (1976)

    Google Scholar 

  20. Jabłońska, S., Chorzelski, T. P., Jarz cabek-Chorzelska, M., Beutner, E. H.: Studies in immunoder-matology. VII. Four compartment system studies of IgG in stratum corneum and of stratum corneum antigen in biopsies of psoriasis and control dermatosen. Int. Arch. Allergy 48, 324–340 (1975)

    Article  PubMed  Google Scholar 

  21. Jabłońska, S., Chorzelski, T. P., Jarz cabek-Chorzelska, M., Beutner, E. H.: Immunofluorescent findings in psoriasis of the scalp. In: Biology and disease of the hair, Toda, K., Ishibashi, Y., Hori, Y., Morikawa, F. (eds.), pp. 309–319. Tokyo: University of Tokyo Press 1976

    Google Scholar 

  22. Jabłońska, S., Chorzelski, T. P., Beutner, E. H., Jarz cabek-Chorzelska, M., Chowaniec, O., Maciejowska, E., Rzęsa, G.: Autoimmunity in psoriasis. II. Immunohistologic studies on various forms of psoriasis and the Koebner phenomenon. In Psoriasis, Farber, E. M., Cox, A. J., Jacobs, P. H., Nall, M. L., (eds.), pp. 73–80. New York, N. Y.: Yorke Medical Books 1977

    Google Scholar 

  23. Jabłońska, S., Chorzelski, T. P., Beutner, E. H., Maciejowska, E., Jarz cabek-Chorzelska, M., Rzęsa, G.: Autoimmunity in psoriasis. Relation of disease activity and forms of psoriasis to immunofluorescence findings. Arch. Dermatol. Res. 261, 135–146 (1978a)

    Article  PubMed  Google Scholar 

  24. Jabłońska, S., Beutner, E. H., Jarz cabek-Chorzelska, M., Maciejowska, E., Rzęsa, G., Chowaniec, O., Chorzelski, T. P.: Autoimmunity in psoriasis. International Convocation of Immunology Niagara Falls 1975, (ed.) Milgrom, F. Basel: A. Karger 1978b

    Google Scholar 

  25. Kimura, S., Nishikawa, T.: An immunohistochemical analysis of the deposited immunoglobulins or fibrinogen in parakeratotic psoriatic horny layer and pemphigus skin lesions. Arch. Dermatol. Res. 1261, 55–62 (1978)

    Article  Google Scholar 

  26. King, C. S., Nichols, S., Marks, R.: Is the horny layer abnormal in uninvolved skin of patients with psoriasis. J. Invest. Dermatol. 70, 227 (1978)

    Google Scholar 

  27. Krogh, H. K.: Antibodies in human sera to stratum corneum. Int. Arch. Allergy 36, 415–426 (1969)

    Article  CAS  PubMed  Google Scholar 

  28. Krogh, H. K.: The occurrence of antibodies to stratum corneum in man. Int. Arch. Allergy 37, 649–659 (1970)

    Article  CAS  PubMed  Google Scholar 

  29. Krogh, H. K., Tönder, O.: Immunoglobulins and antiimmunoglobulin factors in psoriatic lesions. Clin. Exp. Immunol. 10, 623–634 (1972)

    CAS  PubMed  PubMed Central  Google Scholar 

  30. Langner, A., Christophers, E., Bisenkamp, U., Michałowski, P.: Chemotaxis in psoriasis. Br. J. Dermatol. (in press 1978)

  31. Lazurus, G. S., Yost, F. J., Thomas, Ch. A.: Polymorphonuclear leukocytes: possible mechanisms of accumulation in psoriasis. Science 198, 1162–1163 (1977)

    Article  Google Scholar 

  32. Marks, R.: Epidermal activity in the involved and uninvolved skin of patients with psoriasis. Br. J. Dermatol. 98, 399–404 (1978)

    Article  CAS  PubMed  Google Scholar 

  33. Meland, J. A., Krogh, H. K., Tönder, O.: Heterogeneity of antigen from callus of man. Int. Arch. Allergy 46, 619–628 (1974)

    Article  Google Scholar 

  34. Rimbaud, P., Meynadier, J., Guilhou, J. J., Clot, J.: Anti IgG activity on peripheral blood lymphocytes in psoriasis. Arch. Dermatol. 108, 371–373 (1973)

    Article  CAS  PubMed  Google Scholar 

  35. Salo, O. P., Kousa, M., Mustakallio, K. K., Lassus, A.: Demonstration of fibrin in skin diseases. II. Psoriasis. Acta Dermatol. Venereol. (Stockh.) 52, 295–297 (1972)

    CAS  Google Scholar 

  36. Schellender, F., Marks, R.: The epidermal response to subepidermal inflammation. Br. J. Dermatol. 88, 363–367 (1973)

    Article  Google Scholar 

  37. Swierczyńska, Z., Rdułtowska, M., Maciejowska, E., Jabłońska, S.: Circulating immune complexes in patients with psoriasis. Reumatologia. In press (in Polish) 1978

  38. Tagami, M., Ofuji, S.: Leukotactic properties of soluble substances in psoriasis scale. Br. J. Dermatol., 95, 1–8 (1976)

    Article  CAS  PubMed  Google Scholar 

  39. Tagàmi, M., Ofuji, S.: Characterization of a leukotactic factor derived from psoriatic scale. Br. J. Dermatol. 97, 509–518 (1977)

    Article  PubMed  Google Scholar 

  40. Theodoridis, A., Panas, E., Perissios, A., Varelzidis, A., Moutzouris, Ch., Capetanakis, J.: I. Immunologie du psoriasis Essai de l'immunofluorescence directe dans le psoriasis. Ann. Dermatol. Syphil. (Paris) 103, 573–575 (1976)

    Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Dermatology, School of Medicine, Koszykowa 82a, 02-008, Warsaw, Poland

    Stefania Jablonska, Ernst H. Beutner & Walter L. Binder

  2. Department of Microbiology, Schools of Medicine and Dentistry, Suny, 14214, Buffalo, N.Y., USA

    Maria Jarzabek-Chorzelska, Genowefa Rzęsa & Olena Chowaniec

Authors
  1. Stefania Jablonska
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  2. Ernst H. Beutner
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  3. Walter L. Binder
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  4. Maria Jarzabek-Chorzelska
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  5. Genowefa Rzęsa
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  6. Olena Chowaniec
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Additional information

These studies were supported by the Polish Academy of Sciences Grant Nr. 10.5.07.2.1 and the Summerhill Foundation

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Jablonska, S., Beutner, E.H., Binder, W.L. et al. Immunopathology of psoriasis. Arch Dermatol Res 264, 65–71 (1979). https://doi.org/10.1007/BF00417280

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