Summary
Total antibiotic concentration of tetracycline hydrochloride was determined in the ocular structures of rabbits by radioactive tracer method. Concentration of tetracycline of 0.1 to 5 μg/g, adequate to inhibit the growth of bacteria of high or medium susceptibility, was measured from all ocular structures with the exception of the lens. Tetracycline concentration in the aqueous humor was inferior to that in the vascularized ocular tissues and to that in the cornea. Vitreous body tetracycline level, about 0.3 μg/g, was about half of the concentration in the aqueous humor. The disruption of the blood-aqueous barrier following paracentesis led to an immediate increase of tetracycline concentration in the anterior structures of the eye.
Similar content being viewed by others
References
Abraham, R.K., Burnett, H.H.: Tetracycline and chloramphenicol studies on rabbit and human eyes. Arch. Ophthal. 54, 641–659 (1955)
Bleeker, G.M., Maas, E.R.: The penetration of aureomycin, terramycin and chloramphenicol in the ocular tissues. Ophthalmologica (Basel) 130, 1–8 (1955)
Bloome, M.A., Golden, B., McKee, A.P.: Antibiotic concentration in ocular tissues. Penecillin G and dihydrostreptomycin. Arch. Ophthal. 83, 78–83 (1970)
Cannon, E.J., Nichols, A.C., Leopold, I.H.: Studies on the intraocular penetration and toxicity of terramycin. Arch. Ophthal. 47, 344–349 (1952)
Douvas, N.G., Featherstone, R.M., Braley, A.E.: Role of terramycin in ophthalmology. Arch. Ophthal. 46, 57–68 (1951)
Ducrey, N., Faggioni, R.: Etude et résultats d'un traitement antibiotique standardisé après plaie perforante du globe oculaire. Ophthalmologica (Basel), 170, 174–179 (1975)
Faris, B.M., Uwaydah, M.M.: Intraocular penetration of semisynthetic penicillins. Methicillin, cloxacillin, ampicillin and carbpenicillin studies in experimental animals with a review of the literature. Arch. Ophthal. 92, 501–505 (1974)
Furgiuele, P.P.: New antibiotics: Their intraocular penetration. Amer. J. Ophthal. 58, 443–446 (1964)
Grove, D.C., Randall, W.A.: Assay methods of antibiotics. A laboratory manual. New York: Medical Encyclopedia 1955
Hald, A.: Statistical theory with engineering applications. London: Wiley 1952
Jailing, B., Malmborg, A.-S., Lindman, A., Boréus, L.O.: Evaluation of a micromethod for determination of antibiotic concentration in plasma. Europ. J. Clin. Pharmacol. 4, 150–158 (1972)
Knothe, H., Moog, E., Vogel, F., Fabricius, K.: Konzentrationsabläufe des Tetracyclins im Kammerwasser des Menschen nach systemischen Verabreichungen. Klin. Mbl. Augenheilk. 156, 843–850 (1970)
Moog, E.: Pharmakokinetische Probleme am Auge, dargestellt am Beispiel der Tetracycline. Ber. Dtsch. Ophthal. Ges. 70, 442–445 (1969)
Moog, E., Knothe, H.: Der Übertritt verschiedener Tetracycline ins Kammerwasser des Menschen in Abhängigkeit von ihrer Eiweissbindung im Blutserum. Ber. Dtsch. Ophthal. Ges. 69, 536–539 (1968)
Pápai, L., Kahán, I.L.: Indikationen und Grenzen der lokalen tri-Methacyclin-Behandlung von pyogenen Infektionen des Auges. Klin. Mbl. Augenheilk. 169, 372–376 (1976)
Salminen, L.: Effect of paracentesis on ocular cloxacillin concentration. Acta Ophthal. (in press, 1977a)
Salminen, L.: Cloxacillin distribution in the rabbit eye after intravenous injection. Acta Ophthal. (in press, 1977b)
Salminen, L.: Ampicillin penetration into the rabbit eye. Manuscript. (1977c)
Saubermann, G.: Untersuchungen über das Eindringen antibiotischer Substanzen im Kammerwasser und Glaskörper des menschlichen Auges. Bibl. Ophthal. (Basel) 46, 1–70 (1956)
Walter, A., Heilmeyer, L.: Antibiotika Fibel. Stuttgart: Thieme 1969
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Salminen, L. Penetration of ocular compartments by tetracyclines. Albrecht von Graefes Arch. Klin. Ophthalmol. 204, 189–199 (1977). https://doi.org/10.1007/BF00414846
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00414846