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Experimental cryosurgical lesion of the optic nerve

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Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie Aims and scope Submit manuscript

Abstract

The right optic nerves of three cynomolgus monkeys were frozen under direct visualization after a modified Kröhnlein operation. Left optic nerves were subjected to an identical procedure without freezing. Postoperatively, visual evoked responses (VERs) could not be obtained by stimulating right eyes, while electroretinograms from both eyes and VERs obtained by stimulating left eyes were normal. Extensive lesions which were found in the right optic nerves of all animals were histologically similar to those obtained by freezing in the brain.

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References

  • DeVoe RG, Ripps H, Vaughan HG (1968) Cortical responses to stimulation of the human fovea. Vision Res 8:135

    Google Scholar 

  • Klatzo I, Piraux A, Laskowski EJ (1958) The relationship between edema, blood-brain barrier, and tissue elements in a local brain injury. J Neuropath Exp Neurol 17:548

    Google Scholar 

  • Laqua H, Machemer R (1976) Repair and adhesion mechanisms of the cryotherapy lesion in experimental retinal detachment. Am J Ophthalmol 81:833

    Google Scholar 

  • Lincoff H, and Kreissig J (1971) The mechanism of cryosurgical adhesion. 4. Electronmicroscopy. Am J Ophthalmol 71:674

    Google Scholar 

  • Meryman HT (1956) Mechanics of freezing in living cells and tissue. Science 124:515

    Google Scholar 

  • Miyazaki Y, Ervin FR, Siegfried J, Richardson EP, Mark VH (1963) Localized cooling in the central nervous system. Arch Neurol 9:392

    Google Scholar 

  • Smith RS, Boyle E, Rudt EA (1977) Cyclocryotherapy. Arch Ophthalmol 95:284

    Google Scholar 

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Authors and Affiliations

  1. The Departments of Ophthalmology, Neurology and Anatomy, Boston University, School of Medicine, 80 E. Concord Street, 02118, Boston, Mass., USA

    John I. Loewenstein & Simmons Lessell

Authors
  1. John I. Loewenstein
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  2. Simmons Lessell
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Additional information

Supported by: NIH/NEI Fellowship # 5F32EY05223-02 (Dr. Loewenstein), General Research Support Grant (Dr. Lessell), Boston University, School of Medicine

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Loewenstein, J.I., Lessell, S. Experimental cryosurgical lesion of the optic nerve. Albrecht von Graefes Arch. Klin. Ophthalmol. 215, 97–103 (1980). https://doi.org/10.1007/BF00414467

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  • DOI: https://doi.org/10.1007/BF00414467

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