Summary
Using climbing rope and bar-pressing behavior methods, rats were rendered tolerant to Δ 9-THC, cannabis extract, mescaline and LSD-25. Cross-tolerance experiments showed that rats refractory to Δ 9-THC and cannabis extract were still sensitive to mescaline and LSD-25, and vice-versa.
These results suggest that, in spite of the similarity of the clinical symptoms produced in man by the 3 drugs, Δ 9-THC may have its psychotomimetic effects produced by different mechanisms from those of LSD-25 and mescaline.
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This work was partially supported by a grant from Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP).
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Silva, M.T.A., Carlini, E.A., Claussen, U. et al. Lack of cross-tolerance in rats among (−) Δ9-trans-tetrahydrocannabinol (Δ9-THC), cannabis extract, mescaline and lysergic acid diethylamide (LSD-25). Psychopharmacologia 13, 332–340 (1968). https://doi.org/10.1007/BF00414344
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DOI: https://doi.org/10.1007/BF00414344