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The blood-aqueous barrier and its permeability for proteins of different molecular weight

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Summary

In aqueous humors and sera from 44 patients with cataracts, albumin, IgG, and α-1-antitrypsin were measured using radial immunodiffusion. The mean concentrations of the three proteins were significantly smaller than values found in aqueous humors taken post mortem, but corresponded well to values found in cerebrospinal fluid. No statistically significant difference was found between men and women, normotensives and hypertensives, and patients with or without myopia of higher degree (> 6 diopters). A slight increase in protein concentrations in older patients and a relative decrease of α-1-antitrypsin is described. The aqueous humor-serum quotients of the different proteins showed a higher correlation than did the concentration of the proteins in aqueous humors.

Zusammenfassung

Im Kammerwasser und Serum von 44 an Cataract operierten Patienten wurden mit Hilfe der radialen Immundiffusion Albumin, IgG und α-1-Antitrypsin bestimmt. Die Mittelwerte waren gegenüber Werten im KW, das post mortem gewonnen wurde, deutlich erniedrigt, stimmen jedoch gut mit den Normwerten des Liquor cerebrospinalis überein. Es fand sich kein statistisch gesicherter Unterschied zwischen Männern und Frauen, Hypertonikern und Normotensiven, sowie Myopen (über 6 dptr) und Patienten mit nur geringen Brechungsfehlern. Es ließ sich jedoch ein schwacher Anstieg der Proteinkonzentrationen im höheren Alter sowie eine relative Verminderung von α-1-Antitrypsin feststellen. Es besteht eine engere Korrelation zwischen den KW-Serum-Quotienten der einzelnen Proteine, als zwischen den Konzentrationen der Proteine im KW selbst.

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Authors and Affiliations

  1. Institut für Medizinische Computerwissenschaften der Universität Wien, A-1090, Wien, Österreich

    Günther Grabner, Georg Zehetbauer, Heinz Bettelheim, Christine Hönigsmann & Wolfgang Dorda

  2. II. Univ.-Augenklinik, Alserstraße 4, A-1090, Wien, Österreich

    Günther Grabner

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  1. Günther Grabner
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  2. Georg Zehetbauer
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  3. Heinz Bettelheim
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  4. Christine Hönigsmann
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  5. Wolfgang Dorda
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Grabner, G., Zehetbauer, G., Bettelheim, H. et al. The blood-aqueous barrier and its permeability for proteins of different molecular weight. Albrecht von Graefes Arch. Klin. Ophthalmol. 207, 137–148 (1978). https://doi.org/10.1007/BF00414311

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