Abstract
We studied the content of ciliary neurotrophic factor (CNTF) in the lacrimal fluid, the aqueous humor, and the blood serum in 40 patients (40 eyes) with age-related cataracts. Collection of stimulated lacrimal fluid was performed by a pipette on the day preceding surgery; the aqueous humor and the blood were sampled during the phacoemulsification of a cataract. CNTF was measured using an enzyme immunoassay. On average, the concentration of CNTF in patients was 43.0 ± 21.2 pg/mL in the lacrimal fluid, 58.7 ± 26.4 pg/mL in the aqueous humor, and 4.4 ± 2.6 pg/mL in the blood serum. The concentration of CNTF in the aqueous humor correlated well with its content in the lacrimal fluid (Pearson’s correlation coefficient was 0.66, P < 0.000) and exceeded it on average by a factor of 1.4 ± 0.5. The data we obtained may be used for an approximate evaluation of the CNTF concentration in the aqueous humor on the basis of an analysis of the lacrimal fluid.
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Original Russian Text © A.A. Shpak, A.B. Guekht, T.A. Druzhkova, K.I. Kozlova, A.V. Golovin, N.V. Gulyaeva, 2015, published in Neirokhimiya, 2015, Vol. 32, No. 4, pp. 330–333.
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Shpak, A.A., Guekht, A.B., Druzhkova, T.A. et al. Ciliary neurotrophic factor in patients with age-related cataract. Neurochem. J. 9, 311–314 (2015). https://doi.org/10.1134/S1819712415040169
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DOI: https://doi.org/10.1134/S1819712415040169