Summary
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1.
The spectrum of effects produced with single doses of N,N-dimethyltryptamine (DMT) in 6 nontolerant human subjects resembled those produced with lysergic acid diethylamide (LSD). Either drug produced an elevation in systolic blood pressure, a decrease in the threshold for the kneejerk, pupillary dilatation, and a mental response characterized by anxiety, perceptual distortions and hallucinations. The onset and duration of action was shorter with DMT (0.5 mg/kg) as compared to LSD (1.5 mcg/kg), but the maximum intensity of effects with respect to each parameter was equivalent for both drugs.
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Following the chronic administration of LSD only a mild degree of cross tolerance to the mental response could be demonstrated with DMT (0.5 mg/kg) in subjects highly tolerant to the pupillary, kneejerk, and mental effects of LSD (3.0 mcg/kg).
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3.
It is inferred that the site or mechanism which is altered during LSD tolerance is not one which is primarily concerned with the action of DMT.
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Rosenberg, D.E., Isbell, H., Miner, E.J. et al. The effect of N,N-dimethyltryptamine in human subjects tolerant to lysergic acid diethylamide. Psychopharmacologia 5, 217–227 (1964). https://doi.org/10.1007/BF00413244
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DOI: https://doi.org/10.1007/BF00413244