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The effects of psychotropic drugs on the double alley frustration effect

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Summary

Central nervous system stimulants (amphetamine, methylphenidate), depressants (sodium amobarbital, reserpine, tetrabenezine, chlorpromazine) and anti-depressants (iproniazid, pargyline) were administered intraperitoneally to rats prior to their daily trials in an Amsel double runway in an attempt to modify the frustration effect using within-subject comparisons. Absolute running speeds following reinforcement and nonreinforcement were markedly affected by the drugs. However, in contradistinction to conditioned frustration which has proven amenable to pharmacological intervention, the primary frustration in the present paradigm, involving a response that immediately follows nonreward, proved highly resistant to modification.

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Authors and Affiliations

  1. Department of Psychology, University of Illinois, Chicago, Illinois

    P. E. Freedman & Alexander J. Rosen

Authors
  1. P. E. Freedman
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  2. Alexander J. Rosen
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Additional information

This research was supported, in part, by a grant from the Graduate Research Board of the University of Illinois. The authors acknowledge the assistance of A. Strojney, E. Gentry, V. Williams, L. Rosenberg, K. Yamamoto, and R. Wyer, Jr., in the collection and analysis of the data.

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Freedman, P.E., Rosen, A.J. The effects of psychotropic drugs on the double alley frustration effect. Psychopharmacologia 15, 39–47 (1969). https://doi.org/10.1007/BF00410799

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  • DOI: https://doi.org/10.1007/BF00410799

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