Summary
The present paper records the case of a young man, aged 19, with influenza followed suddenly by a Cogan-I-syndrome. The corneal infiltrations recede after local treatment with prednisolone, an effect which cannot be observed at the beginning of the disease under the same therapy. At the end of the illness only a few corneal alterations are detectable. Both vestibula are inactive, the patient remains deaf except for residual hearing on the left side.
Possible causes of the syndrome are discussed with the aid of the available literature, and diseases with similar symptomatology are mentioned.
Zusammenfassung
Es wird über einen 19jährigen Mann berichtet, der nach einem grippalen Infekt überraschend an einem Cogan-I-Syndrom erkrankte. Die cornealen Infiltrate bilden sich nach einer lokalen Prednisolon-Behandlung weitgehend zurück, ein Effekt, der zu Beginn der Erkrankung nicht beobachtet werden kann. Am Ende der Erkrankung sind noch geringe Hornhautveränderungen nachweisbar, beide Vestibulae sind unerregbar, bis auf ganz schwache Hörreste links bleibt der Patient taub.
Es werden anhand der vorliegenden Literatur mögliche Ursachen der Erkrankung diskutiert und Krankheiten mit einer ähnlichen Symptomatologie erwähnt.
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References
Albrite, J. P., Resnick, D. M.: Cogan's syndrome. Arch. Otolaryng. 74, 501 (1961).
Anderson, W. A. D.: Synopsis of pathology, second edition, 741 pp., 584. St. Louis: Mosby 1948.
Bammer, H., Oswald, A., Schaltenbrand, G.: Über das Cogan-Syndrom. Nervenarzt 30, 315–319 (1959).
Bennet, F. M.: Bilateral recurrent episcleritis. Amer. J. Ophthal. 55, 815–818 (1963).
Boyd, G. G.: Cogan's syndrome; report of two cases with signs and symptoms suggesting periarteritis nodosa. Arch. Otolaryng. 65, 24–25 (1957).
Cogan, D. G.: Syndrome of non-syphilitic interstitial keratitis and vestibuloauditory symptoms. Arch. Ophthal. 33, 144–149 (1945).
Cogan, D. G.: Nonsyphilitic interstitial keratitis and vestibuloauditory symptoms: report of four additional cases. Arch. Ophthal. 42, 42–49 (1949).
Cogan, D. G., Dickersin: Nonsyphilitic interstitial keratitis with vestibulo-auditory symptoms—a case with fatal aortitis. Trans. Amer. ophthal. Soc. 61, 113–119 (1963).
Donald, R. A., Gardner, W. J.: Keratitis with deafness. Amer. J. Ophthal. 33, 889–892 (1950).
Duke-Elder, S.: System of ophthalmology, vol. 8, 811 pp., T. 2. London: Henry Kimpton 1965.
Eisenstein, B., Taubenhaus, M.: Nonsyphilitic interstitial keratitis and bilateral deafness (Cogan's syndrome) associated with cardiovascular disease. New Engl. J. Med. 258, 1074–1079 (1958).
Fair, J. R., Levi, G. A.: Keratitis and deafness. Amer. J. Ophthal. 49, 1017–1021 (1960).
Fisher, E. R., Hellstrom, H. R.: Cogan's syndrome and systemic vascular disease. Arch. Path. 72, 572 (1961).
Glocke, D. G., Morgan, C., Hsu, K., Lockshin, M.: Association between polyarteritis and Australia antigen. Lancet 1970 II, 1149–1152.
Grandström, K. C., Nylèn, C. O.: Crises de vertige de Menière et crises d'iritis avec oedème de Quincke dans les paupières chez une meme patiente. Acta otolaryng. (Stockh.) 26, 717–725 (1938).
Hedges, T. R., Taylor, G. W.: Uveal and vestibuloauditory disease with sarcoid. Arch. Ophthal. 48, 88 (1952).
Hoekenga, M. T.: Ocular toxicity of Whipcide (3-meth.-1-pentyn-3-yl acid phthalate) in humans. J. Amer. med. Ass. 161, 1252–1253 (1956).
Ingalls, R. G.: Bilateral uveitis and keratitis accompanying periarteritis nodosa. Trans Amer. Acad. Ophthal. Otolaryng. 55, 630–631 (1951).
Kohra, T.: Cited by Süllmann, H.: Biochemie des Auges. Ophthalmologica (Basel) 96, 37–64 (1938).
Logue, R. B., Mullins, F.: Polyarteritis nodosa: report of 11 cases with review of recent literature. Ann. intern. Med. 24, 11–26 (1946).
Lindsay, J. R., Zuidema, J. J.: Inner ear deafness of sudden onset. Laryngoscope (St. Louis) 60, 238–263 (1950).
McGrath, H.: Meniére's disease associated with traumatic hyphemia and glaucoma. Amer. J. Ophthal. 34, 241–245 (1952).
McNeil, N. F., Berke, M., Rheingold, I. M.: Polyarteritis nodosa causing deafness in adult: report of case with special reference to concepts about disease. Ann. intern. Med. 37, 1253–1267 (1952).
Mogan, R. F., Baumgartner, C. J.: Meniére's disease complicated by recurrent interstitial keratitis: excellent results following cervical ganglionektomy. West. J. Surg. 42, 628–631 (1934).
Norton, E. W. D., Cogan, D. G.: Syndrome of nonsyphilitic interstitial keratitis and vestibulo-auditory symptoms. Arch. Ophthal. 61, 695–697 (1959).
Oliner, L., Taubenhaus, M., Shapira, Th., Leshin, N.: Nonsyphilitic interstitial keratitis and bilateral deafness associated with essential polyangitis (Periarteritis nodoa). New Engl. J. Med. 248, 1001–1008 (1953).
Robson, J. T.: Cervical sympathektomy in nonsyphilitic interstitial keratitis with vestib.-audit. symptoms: report of a case. Arch. Ophthal. 44, 243–244 (1950).
Rose, G.: Polyarteritis and Australia antigen. Lancet 1970 II, 1308.
Rosen, E.: Interstitial keratitis and vestibuloauditory symptoms following vaccination. Arch. Ophthal. 41, 24–31 (1949).
Velhagen, K.: Der Augenarzt, vol. 3, 319 pp. Stuttgart: G. Thieme 1960.
Williams, H. L.: A concept of allergy as autonomic dysfunction suggested as an improved working hypothesis. Trans. Amer. Acad. Ophthal. otolaryng. 55, 123–146 (1950).
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Seel, J. Cogan-I-syndrome interstitial keratitis with sudden deafness. Albrecht v. Graefes Arch. klin. exp. Ophthal. 185, 281–287 (1972). https://doi.org/10.1007/BF00410759
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DOI: https://doi.org/10.1007/BF00410759