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Corneal Histopathology in Stevens-Johnson Syndrome: A Case Report and Review of Literature

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Abstract

Stevens-Johnson syndrome is a life-threatening, immune-mediated, acute inflammatory disorder of the mucocutaneous membranes. It affects people of almost any age and has a high mortality and morbidity rate. Therefore, histopathological confirmation of the diagnosis is essential. Ocular involvement occurs in more than 50% of the affected patients. Here, we report a case of Stevens-Johnson syndrome with ocular involvement in a 10-year-old boy suffering from pain, burning, stinging, and decreased vision in both eyes for over 2 years. Histopathological findings were consistent with the changes due to the syndrome. Stevens-Johnson syndrome affects various mucous membranes along with the skin. Ocular involvement may manifest both acutely and chronically and causes morbidities. A careful clinical and histopathologic examination is required in order to give the correct diagnosis.

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References

  1. Pereira FA, Mudgil AV, Rosmarin DM. Toxic epidermal necrolysis. J Am Acad Derm. 2007;56:181–200.

    Article  Google Scholar 

  2. Ferrandiz-Pulido C, Garcia-Patos V. A review of causes of Stevens-Johnson syndrome and toxic epidermal necrolysis in children. Arch Dis Child. 2013;98(12):998–1003.

    Article  Google Scholar 

  3. Sotozono C, Ang LP, Koizumi N, et al. New grading system for the evaluation of chronic ocular manifestations in patients with Stevens-Johnson syndrome. Ophthalmology. 2007;114:1294–302.

    Article  Google Scholar 

  4. Levi N, Bastuji-Garin S, Mockenhaupt M, et al. Medications as risk factors of Stevens-Johnson syndrome and toxic epidermal necrolysis in children: a pooled analysis. Pediatrics. 2009;123:297–304.

    Article  Google Scholar 

  5. Dodiuk-Gad RP, Chung WH, Valeyrie-Allanore L, Shear NH. Stevens-Johnson syndrome and toxic epidermal necrolysis: an update. Am J Clin Dermatol. 2015;16(6):475–93.

    Article  Google Scholar 

  6. Chow LLW, Shih KC, Chan JCY, Lai JSM, Ng ALK. Comparison of the acute ocular manifestations of Stevens-Johnson syndrome and toxic epidermal necrolysis in Chinese eyes: a 15-year retrospective study. BMC Ophthalmol. 2017;17(1):65.

    Article  Google Scholar 

  7. Wetter DA, Camilleri MJ. Clinical, etiologic, and histopathologic features of Stevens-Johnson syndrome during an 8-year period at Mayo Clinic. Mayo Clin Proc. 2010;85(2):131–8.

    Article  Google Scholar 

  8. Hazin R, Ibrahimi OA, Hazin MI, Kimyai-Asadi A. Stevens-Johnson syndrome: pathogenesis, diagnosis, and management. Ann Medicine. 2008;40:129–38.

    Article  Google Scholar 

  9. Chang YS, Huang FC, Tseng SH, Hsu CK, Ho CL, Sheu HM. Erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis: acute ocular manifestations, causes, and management. Cornea. 2007;26(2):123–9.

    Article  Google Scholar 

  10. Swamynathan SK, Wells A. Conjunctival goblet cells: ocular surface functions, disorders that affect them, and the potential for their regeneration [published correction appears in Ocul Surf. 2020 Feb 28;:]. Ocul Surf. 2020;18(1):19–26.

  11. López-García JS, Rivas Jara L, García-Lozano CI, Conesa E, de Juan IE, Murube del Castillo J. Ocular features and histopathologic changes during follow-up of toxic epidermal necrolysis. Ophthalmology. 2011;118(2):265–71.

  12. Ueta M. Pathogenesis of Stevens-Johnson syndrome/toxic epidermal necrolysis with severe ocular complications. Front Med (Lausanne). 2021;8: 651247.

    Article  Google Scholar 

  13. Ueta M. Findings by an ınternational collaboration on SJS/TEN with severe ocular complications. Front Med (Lausanne). 2021;8: 649661.

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Pathology, The Council of Forensic Medicine, Fevzi Cakmak Mah. Kimiz Sok. No:1 Bahcelievler, Istanbul, Turkey

    Eylul Gun

  2. Department of Pathology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey

    Erdener Ozer

Authors
  1. Eylul Gun
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  2. Erdener Ozer
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Contributions

EG contributed to the literature review and manuscript preparation. EO contributed to the diagnosis, manuscript preparation, and editing.

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Correspondence to Eylul Gun.

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The authors declare no competing interests.

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Gun, E., Ozer, E. Corneal Histopathology in Stevens-Johnson Syndrome: A Case Report and Review of Literature. SN Compr. Clin. Med. 4, 122 (2022). https://doi.org/10.1007/s42399-022-01201-5

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  • DOI: https://doi.org/10.1007/s42399-022-01201-5

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