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Electron microscope studies on the structure of collagen fibrils by negative staining

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Summary

Electron microscope studies on collagen from rat-tail tendon using a negative staining technique have indicated the presence of filaments 15–20 Å in diameter within the fibres. These filaments are thought to correspond to the collagen macromolecule.

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Authors and Affiliations

  1. Medical Research Council Unit for Molecular Biology and Electron Microscope Section, Cavendish Laboratory, University of Cambridge, Cambridge, England

    W. J. Tromans, R. W. Horne, G. A. Gresham & A. J. Bailey

  2. Institute of Animal Physiology, Babraham, Cambridge, England

    W. J. Tromans, R. W. Horne, G. A. Gresham & A. J. Bailey

  3. Department of Pathology, University of Cambridge, Cambridge, England

    W. J. Tromans, R. W. Horne, G. A. Gresham & A. J. Bailey

  4. Low Temperature Research Council, Cambridge, England

    W. J. Tromans, R. W. Horne, G. A. Gresham & A. J. Bailey

Authors
  1. W. J. Tromans
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  2. R. W. Horne
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  3. G. A. Gresham
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  4. A. J. Bailey
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Additional information

We would like to thank Prof. R. A. McCance for supplying the specimens of fowl tendon used in this investigation, and Dr. F. H. C. Crick, Dr. S. Fitton-Jackson and Dr. T. Gillman for a number of valuable discussions. One of us (W. J. T.) wishes to thank the Medical Research Council for financial support during this work.

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Tromans, W.J., Horne, R.W., Gresham, G.A. et al. Electron microscope studies on the structure of collagen fibrils by negative staining. Z.Zellforsch 58, 798–802 (1962). https://doi.org/10.1007/BF00410661

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  • DOI: https://doi.org/10.1007/BF00410661

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