Skip to main content
SpringerLink
Log in

Cellular decay in the rat retina during normal post-natal development: A preliminary quantitative analysis of the basic endogenous rhythm

  • Published:
Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie Aims and scope Submit manuscript

Abstract

The diurnal variation in the appearance of cell death in the rat retina during postnatal development was investigated. The frequency and the morphology of the necrotic cells and the mitotic figures were studied by light and electron microscopy at various stages of ontogenesis and at specified times during each day. Preliminary results show that there is a varying exponential behaviour of mean necrosis-densities at certain periods each day. This chronobiological pattern and the general problems of physiological cellular decay in the developing retina are discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Badtke, G.: Entwicklungsmechanische Faktoren bei der Formgebung des embryonalen Augapfels. A. v. Graefes Arch. klin. exp. Ophthal. 152, 671–689 (1952)

    Google Scholar 

  • Brattgard, S.-O.: The importance of adequate stimulation for the chemical composition of retinal ganglion cells during early postnatal development. Acta. radiol. (Stockh.) 96, 80–98 (1952)

    Google Scholar 

  • Bünning, E.: The physiological clock. 3rd ed. London: English University Press; New York-Heidelberg-Berlin: Springer (1973)

    Google Scholar 

  • Chu-Wang, I.W., Oppenheim, R.W.: Cell deaths of the motor neurons in the chick embryo spinal cord. J. Comp. Neurol. 177, 33–58 (1978)

    Google Scholar 

  • Dinnendahl, L., Kramer, G.: Über Änderungen im Aufbau der Augen beim Wachstum von Katzenhaien (Scylliorhinus canicula und s. stellare). Pubbl. Staz. zool. Napoli 26, 28–35 (1955)

    Google Scholar 

  • Echlin, P.: Intra-cytoplasmic membranous inclusion in the blue green alga Anacytis ridulans. Arch. Mikrobiol. 49, 267–274 (1964)

    Google Scholar 

  • Eckerlein, H.: Über die durch Anhäufung von Mitosen angezeigten Wachstumsorte eines menschlichen Augenbechers. Med. Diss. Würzburg, 1937

  • Forsberg, J.G., Källen, B.: Cell deaths during embryogenesis. Rev. Roum. Embryol. Cytol., Série d'Embryol. (Bucharest) 5, 91–102 (1968)

    Google Scholar 

  • Glücksmann, A.: Development and differentiation of the tadpole eye. Brit. J. Ophthal. 24, 153–178 (1940)

    Google Scholar 

  • Glücksmann, A.: Cell deaths in normal vertebrate ontogenity. Biol. Rev. 26, 59–86 (1951)

    Google Scholar 

  • Glücksmann, A.: Cell death in normal development. Arch. Biol. (Liège) 76, 419–437 (1965)

    Google Scholar 

  • Hall, M.O.: Phagocytosis of light- and dark-adapted rod outer segments by cultured pigment epithelium. Science, 202, 526–528 (1978)

    Google Scholar 

  • Hebel, R.: Entwicklung und Struktur der Retina und des Tapetum lucidum des Hundes. Adv. Anat. Embryol. 45, 1–93 (1971)

    Google Scholar 

  • Hollyfield, J.G., Rayborn, M.E.: Photoreceptor outer segment development: light and dark regulate the rate of membrane addition and loss. Invest. Ophthal. Visual Sciences 18, 117–132 (1979)

    Google Scholar 

  • Ito, S., Winchester, R.J.: The fine structure of the gastric mucosa in the rat. J. Cell Biol. 16, 541–577 (1963)

    Google Scholar 

  • Kuwabara, T., Weidman, T.A.: Development of the prenatal rat retina. Invest. Ophthal. 13, 725–739 (1974)

    Google Scholar 

  • La Vail, M.M.: Rod outer segment disc shedding in the rat retina: relationship to cyclic lighting. Science, 194, 1071–1073 (1976)

    Google Scholar 

  • Mattanza, G.G.: Zur Bedeutung des embryonalen Zelluntergangs im Vorderhirn: I. Untersuchungen am Menschen und bei der Maus. Acta Anat. 85, 96–107 (1973)

    Google Scholar 

  • Müller, G.: Die embryonale Entwicklung eines sich rezessiv vererbenden Merkmals (Kolobom bei der Hausmaus). Wien. Z. Martin-Luther-Univ. 1, 27–43 (1951/52)

    Google Scholar 

  • Norlander, R.H., Edwards, J.S.: Morphological cell death in the postembryonic development of the insect optic lobes. Nature (Lond.) 218, 780–781 (1968)

    Google Scholar 

  • O'Connor, T.M., Wyttenbach, C.R.: Cell death in the embryonic chick spinal cord. J. Cell Biol. 60, 448–459 (1974)

    Google Scholar 

  • O'Day, O., Young, R.W.: Rhythmic daily shedding of outer segment membranes by visual cells in the goldfish. J. Cell Biol. 76, 593–604 (1978)

    Google Scholar 

  • Pilar, G., Landmesser, L.: Ultrastructural differences during embryonic cell deaths in normal and peripherally deprived ciliary ganglia. J. Cell Biol. 68, 339–356 (1976)

    Google Scholar 

  • Reichenow, E.: Die Rückbildungserscheinungen am Anurendarm während der Metamorphose und ihre Bedeutung für die Zellforschung. Arch. mikr. Anat., 72 (1908); cited in Glückmann 1940

  • Remé, Ch. E., Sulzer, M.: Diurnal variation of autophagy in rod visual cells in the rat. A. v. Graefes Arch. klin. exp. Ophthal. 203, 261–270 (1977)

    Google Scholar 

  • Saunders, J.W.: Death in the embryonic system. Science 154, 604–612 (1966)

    Google Scholar 

  • Sievers, J.: Basic two-dye stains for epoxy-embedded 0.3−0.1 μ sections. Stain Technol. 46, 195–199 (1971)

    Google Scholar 

  • Silver, J., Hughes, A.F.W.: The role of cell death during morphogenesis of the mammalian eye. J. Morphol. 140, 159–170 (1973)

    Google Scholar 

  • Silver, J., Hughes, A.F.W.: The relationship between morphogenetic cell death and the development of congenital anophthalmia. J. Comp. Neurol. 157, 281–302 (1974)

    Google Scholar 

  • Sokal, G.S., Holt, R.K.: Cell death during normal development of the abducens nucleus. Exp. Neurol., 54, 533–545 (1977)

    Google Scholar 

  • Spadaro, A., de Simone, I., Puzzolo, D.: Ultrastructural data and chronobiological patterns of the synaptic ribbons in the outer plexiform layer in the retina of albino rats. Acta Anat., 102, 365–373 (1978)

    Google Scholar 

  • Szily, A.v.: Über einleitende Vorgänge bei der ersten Entwicklung der Nervenfasern im Nervus opticus. A. v. Graefes Arch. Ophthal. 81, 67–86 (1912)

    Google Scholar 

  • Theiler, K., Varnum, D.S., Nadeau, J.H., Stevens, L.C., Cagianut, B.: A new allele of ocular retardation: Early development and morphogenetic cell death. Anat. Embryol. 150, 85–97 (1976)

    Google Scholar 

  • Vogel, M.: Postnatal development of the cat's retina. Adv. Anat. Embryol. Cell Biol. 54, 1–66 (1978a)

    Google Scholar 

  • Vogel, M.: Postnatal development of the cat's retina: a concept of maturation obtained by qualitative and quantitative examinations. A. v. Graefes Arch. klin. exp. Ophthal., 208, 93–107 (1978b)

    Google Scholar 

  • Vogt, W.: Über rückschreitende Veränderungen von Kernen und Zellen junger Entwicklungsstadien von Triton cristatus (vorläufige Mitteilung). Sitzungsb. d. Gesellsch. z. Bef. d. ges. Naturwiss. zu Marburg, Nr. 4, (1909), cited by Glückmann 1940

  • Wagner, H.-J.: Der Einfluß von Licht- und Tagesrhythmus auf die “Ribbon-Synapsen” in der Retina. Verh. Anat. Gesellsch. 69, 651–658 (1975)

    Google Scholar 

  • Young, R.W.: Visual cells and the concept of renewal. Invest. Ophthal. 15, 700–725 (1976)

    Google Scholar 

  • Young, R.W.: The daily rhythm of shedding and degeneration of cone outer segment membranes in the Lizard retina. J. Ultrastruct. Res., 61, 172–185 (1977)

    Google Scholar 

  • Zilles, K., Schleicher, A., Wingert, F.: Spontaner Neuronenuntergang im nucl. tractus mesenceph. n. trigemini während der Perinatalzeit einer ontogenetischen Reihe von Albinomäusen. Gegenbaurs morph. Jb. (Leipzig), 121, 289–299 (1975a)

    Google Scholar 

  • Zilles, K., Schleicher, A., Kretschmann, H.-J., Wingert, F.: Quantitative Untersuchungen über das Wachstum der Neuronen- und Gliazellanzahl in Kerngebieten verschiedener Species während der Ontogenese. Verh. Anat. Gesellsch. (Jena), 69, 505–515 (1975b)

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Anatomy, Medical School of Lübeck, Ratzeburger-Allee, 160, D-2400, Lübeck, Federal Republic of Germany

    M. Vogel & K. Möller

Authors
  1. M. Vogel
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. K. Möller
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Vogel, M., Möller, K. Cellular decay in the rat retina during normal post-natal development: A preliminary quantitative analysis of the basic endogenous rhythm. Albrecht von Graefes Arch. Klin. Ophthalmol. 212, 243–260 (1980). https://doi.org/10.1007/BF00410519

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00410519

Keywords

Search

Navigation