Summary
The responsiveness of spleen cells from C57BL/6J mice to various immunogenic stimuli was examined during the progressive growth of a poorly immunogenic fibrosarcoma T241. A strong correlation was observed between the progressive tumor growth and the depression of response to Concanavalin A, lipopolysaccharide, sheep red blood cells, and alloantigens in mixed lymphocyte reaction and cell-mediated lympholysis (CML). The maximum depression of these immune responses occurred when the animals had grown tumors for 3–4 weeks. Furthermore, serum from these animals collected 20 days after tumor transplantation was highly immunosuppressive. The possible mechanisms of tumor-induced immunosuppression have been discussed.
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Gautam, S.C., Gautam, S. & Deodhar, S.D. Influence of progressive growth of a weakly immunogenic fibrosarcoma (T241) on the immune status of mice. J Cancer Res Clin Oncol 101, 265–274 (1981). https://doi.org/10.1007/BF00410112
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DOI: https://doi.org/10.1007/BF00410112