Summary
Thirty-two rabbits were immunized by subcutaneous human serum albumin in Freund's adjuvant and challenged after four weeks by intracorneal injection in both eyes. On a random and blind basis, one of the eyes in each animal received three consecutive injections of antilymphocyte serum obtained from rats and the other eye the same dose of normal rat serum. Statistical analysis of results showed no significant difference between both treatments. Two eyes treated with antilymphocyte serum had limbal necrosis with uveal prolapse.
Zusammenfassung
32 Versuchskaninchen wurden mittels subcutaner Einspritzungen von menschlichem Serumalbumin mit Freunds Adjuvant immunisiert. Nach 4 Wochen erfolgten intracorneale Einspritzungen von menschlichem Serumalbumin in beiden Augen jedes Tieres. Nach dem Doppelblindversuch erhielt in den drei darauffolgenden Tagen ein Auge der Tiere Antilymphocytenserum, welches von Mäusen gewonnen war, intracorneal eingespritzt. Das andere Auge bekam dieselbe Dosis von normalem Mäuseserum. Die statistische Analyse der Resultate zeigte keine signifikativen Unterschiede zwischen den beiden Augen Bei 2 Tieren, die mit Antilymphocytenserum behandelt waren, entwickelte sich eine Nekrose des Limbus mit Prolaps der Uvea.
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Jordano, J. Subconjunctival injection of antilymphocyte serum during corneal hypersensitivity to heterologous albumin. Albrecht von Graefes Arch. Klin. Ophthalmol. 196, 79–83 (1975). https://doi.org/10.1007/BF00410029
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DOI: https://doi.org/10.1007/BF00410029