Summary
The alga Phormidium mucicola was found quite sensitive to antibiotics. Several strains resistant to streptomycin and penicillin were isolated following single and several contacts of antibiotics respectively. The resistant character remained stable during subcultures in drug-free medium. However, to isolate a fully stable and resistant strain of a concentration of penicillin two additional exposures to the same dose were required, unless otherwise, resistance was gradually lost during subcultures in penicillin-free media. This observation has been attributed to the heterogeneous nature of the resistant clones. Neither streptomycin nor penicillin resistant strains revealed cross-resistance to ultraviolet (u.v.) or to themselves.
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Kumar, H. D.: Streptomycin- and penicillin-induced inhibition of growth and pigment production in blue-green algae and production of strains of Anacystis nidulans resistant to these antibiotics. J. exp. Bot. 15, 232–250 (1964).
Miller, C. P., Bohnhoff, M.: The development of bacterial resistance to chemotherapeutic agents. Ann. Rev. Microbiol. 4, 201–222 (1950).
Novick, R. P., Richmond, M. H.: Nature and the interactions of the genetic elements governing penicillinase synthesis in Staphylococcus aureus. J. Bact. 90, 467–480 (1965).
Singh, R. N., Singh, H. N., Sinha, R.: Mutation and recombination in blue-green algae. In: The impact of mendelism on agriculture, biology and medicine. Intern. Symp. Indian Soc. Genet. Plant Breed., New Delhi, pp. 405–430 (1965).
Srivastava, B. S.: Ultraviolet-induced mutations to growth factor requirement and penicillin resistance in a blue-green alga. Arch. Mikrobiol. 66, 234–238 (1969).
Watanabe, T., Fukasawa, T.: Resistance transfer factor and episome in Enterobacteriaceae. Biochem. Biophys. Res. Commun. 3, 660–665 (1960).
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Srivastava, B.S. Sensitivity and resistance of a blue-green alga Phormidium mucicola to streptomycin and penicillin. Archiv. Mikrobiol. 72, 182–185 (1970). https://doi.org/10.1007/BF00409523
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DOI: https://doi.org/10.1007/BF00409523