Summary
Indirect immunofluorescent (IF) studies have demonstrated the presence of antinuclear antibodies (ANA) and antibodies reactive with the intercellular area (IC), basement membrane zone, and basal cells of autologous and allogeneic unburned skin in the sera of acute adult burn patients. Further demonstration in burn patients of the occurrence of peripheral ANA masquerading as IC antibodies is presented. In keeping with previous IF identifications of autoantibodies in burn patients, there was no significant relationship between the frequency and titer of these antibodies according to the extent of total body surface burn area and third degree burn area. The possible role of epithelial antibodies in the maintenance of host resistance, as previously suggested, is considered in brief.
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Ablin RJ, Milgrom F, Kano K, Rapaport FT, Beutner EH (1969) Pemphigus-like antibodies in patients with skin burns. Vox Sang 16:73–75
Ablin RJ, Holder IA (1974) IgG and complement-fixing “pseudo” intercellular autoantibodies following thermal injury Arch Dermatol 109:887–888
Ablin RJ, Holder IA (1976) Immunologic sequelae of thermal injury. I. Frequency and relationship of epithelial antibodies to extent of burn. Clin Immunol Immunopathol 5:195–207
Ablin RJ, Holder IA (1977) Immunologic sequelae of thermal injury. Alterations in complement (Abstract). Clin Chem 23:1155
Ablin RJ, Holder IA (1980) Autoimmune sequelae in burn patients. In: Ninnemann JL (ed) The immune consequences of thermal injury. Williams and Wilkins, Baltimore, pp 180–187
Beutner EH, Sepulvada MR, Barnett EV (1968) Quantitation studies of immunofluorescent staining. Bull WHO 39:587–606
Holder IA, Ablin RJ (1980) Alterations in complement in burn patients. In: Ninnemann JL (ed) The immune consequences of thermal injury. Williams and Wilkins, Baltimore, pp 134–149
Ninnemann JL (1980) The immune consequences of thermal injury. Williams and Wilkins, Baltimore
Thivolet J, Beyvin AJ (1968) Recherche par immunofluorescence d'autoanticorps sériques vis-à-vis des constituants de l'épiderme chez les brûles. Experientia 24:945–946
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Ablin, R.J., Holder, I.A. Immunologic sequelae of thermal injury autoantibodies in acute adult burn patients. Arch Dermatol Res 273, 267–271 (1982). https://doi.org/10.1007/BF00409255
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DOI: https://doi.org/10.1007/BF00409255