Summary
A cell-free extract from mycelium of Streptomyces rimosus producing the antibiotic tylosin, catalyses the formation of TDP-mycarose from TDP-d-glucose and S-adenosyl-l-methionine. The reaction requires NADPH. The product contains a second methylated TDP-sugar with a presently unknown structure. TDP-4-Keto-6-deoxy-d-glucose is an intermediate in the reaction.
Zusammenfassung
Ein zellfreier Extrakt aus Streptomyces rimosus katalysiert die Synthese von TDP-Mycarose aus TDP-d-Glucose und S-Adenosyl-l-methionin. Die Reaktion benötigt NADPH. Das Reaktionsprodukt enthält einen weiteren methylierten TDP-Zucker unbekannter Struktur. Die Reaktion verläuft über TDP-4-Keto-6-desoxy-d-glucose als Zwischenprodukt.
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112. Mitteilung: T. Anke und H. Diekmann: Biosynthesis of Sideramines in Fungi. Rhodotorulic Acid Synthetase from Extracts of Rhodotorula glutinis. FEBS Letters (im Druck).
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Pape, H., Brillinger, G.U. Stoffwechselprodukte von Mikroorganismen. Archiv. Mikrobiol. 88, 25–35 (1973). https://doi.org/10.1007/BF00408838
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DOI: https://doi.org/10.1007/BF00408838