Chlorprothixene (“Truxal”) compared to chlorpromazine

Summary

In a “double-blind” comparative study between chlorprothixene (Truxal) and chlorpromazine treatment in hospitalized, relatively acute patients we found that among all psychotic patients (except the depressive) as well as the hyperactive, physically agitated patients, the 74 chlorprothixene treated patients showed equally good or better improvement than the 89 chlorpromazine treated.

The minor side- effects appeared to be equally frequent during the two treatments, but chlorprothixene seemed to show no serious toxic effects, and particularly the extrapyramidal side-effects were so rare and so little pronounced that we found chlorprothixene to be preferable to chlorpromazine. It should be pointed out that the period of observation was relatively short (in 127 patients less than 7 weeks).