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The effect of the new antibiotic myxothiazol on the respiration of Paracoccus denitrificans

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Abstract

Myxothiazol inhibited the electron transport in the cytochrome b-c 1segment of membrane particles from Paracoccus denitrificans. There remained, however, a residual NADH oxidation of about 10% which was probably due to the presence of an alternative respiratory pathway via cytochrome o. This may also explain why in presence of myxothiazol growth of P. denitrificans is resumed, at a reduced rate, after an adaption period of 1 h.

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Author notes

  1. Georg Thierbach

    Present address: Dept. of Biochemistry, Leeds University, LS2 9JT, Leeds, UK

Authors and Affiliations

  1. Gesellschaft für Biotechnologische Forschung, Abteilung Mikrobiologie, GBF, Mascheroder Weg 1, D-3300, Braunschweig, Germany

    Georg Thierbach & Hans Reichenbach

Authors
  1. Georg Thierbach
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  2. Hans Reichenbach
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Additional information

Article No. 12 on antibiotics from gliding bacteria. For article No. 11 see: G. Thierbach and G. Michaelis, Mol Gen Genet 1986:501–506, 1982

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Thierbach, G., Reichenbach, H. The effect of the new antibiotic myxothiazol on the respiration of Paracoccus denitrificans . Arch. Microbiol. 134, 104–107 (1983). https://doi.org/10.1007/BF00407940

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  • DOI: https://doi.org/10.1007/BF00407940

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