Summary
Polymorphonuclear leukocytes (PMN) from ten patients with chronic stable plaque psoriasis, five of whom had more than 40% skin involvement and five with less than 20% involvement, responded in a dose-related fashion to stimulation with the arachidonic acid lipoxygenase products 5- and 12-hydroxyeicosatetraenoic acid (5- and 12-HETE) and leukotriene B4 (LTB4) in an in vitro chemokinesis assay. There was no significant difference in either the random migration or the chemokinetic response of psoriatic PMN to LTB4 when compared to the responses of PMN from a group of age- and sex-matched healthy controls. Psoriatic PMN migrated further in response to low doses of 5- and 12-HETE although the distance moved after maximal stimulation was no different to that observed in controls. No significant difference was observed in the responses of PMN obtained from patients with less than 20% skin involvement when compared to those with more extensive psoriasis. The small differences measured between the chemokinetic responses of psoriatic and control PMN to the lipoxygenase products tested are unlikely to be of pathogenetic significance.
Similar content being viewed by others
References
Breathnach S, Carrington P, Black M (1981) Neutrophil leukocyte migration in psoriasis vulgaris. J Invest Dermatol 76:271–274
Camp RDR, Mallet AI, Woolard PM, Brain SD, Kobza Black A, Greaves MW (1983) The identification of hydroxy fatty acids in psoriatic skin. Prostaglandins 26:431–449
Czarnetzki B (1983) Increased monocyte chemotaxis towards leukotriene B4 and platelet-activating factor in patients with inflammatory dermatoses. Clin Exp Immunol 54:486–492
Dowd PM, Kobza Black A, Woollard PM, Greaves MW (1985) Leukotriene B4 and 12-HETE: Induction of pharmacological tolerance and clinical significance. Clin Res 33:634A
Kawohl G, Szperalski B, Schröder J, ChristophersE (1980) Polymorphonuclear leukocyte chemotaxis in psoriasis: Enhancement by self-activated serum. Br J Dermatol 103:527–533
Krueger GG, Hill HR, Jederberg WW (1978) Inflammatory and immune cell function in psoriasis: A subtle disorder. 1. In vivo and in vitro survey. J Invest Dermatol 71:189–194
Majewski S, Jablonska S, Langer A, Pawinska M, Szmurulo A (1985) The adherence to human endothelium and plastic of neutrophils from psoriatic patients and the effects of psoriatic patients' sera on normal neutrophils. Br J Dermatol 112:655–662
Michaelsson G (1980) Increased chemotactic activity of neutrophil leukocytes in psoriasis. Br J Dermatol 103:351–356
Normann SJ, Schardt M, Sorkin E (1985) Antileukocyte activity. 1. Systemic inhibition of cellular emigration following local inflammation. J Leukocyte Biol 37:319–330
Pigatto PD, Radaelli A, Tadini G, Polenghi MM, Brambilla L, Altomare G, Carandente F (1985) Circadian rhythm of the in vivo migration of neutrophils in psoriatic patients. Arch Dermatol Res 277:185–189
Smith MJH, Walker JR (1980) The effects of some antirheumatic drugs on an in vitro model of human polymorphonuclear leukocyte chemokinesis. Br J Pharmacol 69:473–478
Tigalonowa M, Glinski W, Jablonska S (1983) In vivo mobilization of polymorphonuclear leukocytes in psoriasis: Relationships to clinical parameters and serum inhibitory factors. J Invest Dermatol 81:6–9
Wahba A, Cohen H, BarEli M, Galily R (1978) Enhanced chemotactic and phagocytic activities of leukocytes in psoriasis vulgaris. J Invest Dermatol 71:186–188
Wong E, Camp RD, Greaves MW (1985) The responses of normal and psoriatic skin to single and multiple topical applications of leukotriene B4. J Invest Dermatol 84:421–424
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Cunningham, F.M., Wong, E., Woollard, P.M. et al. The chemokinetic response of psoriatic and normal polymorphonuclear leukocytes to arachidonic acid lipoxygenase products. Arch Dermatol Res 278, 270–273 (1986). https://doi.org/10.1007/BF00407736
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00407736