Skip to main content
SpringerLink
Log in

Defective natural-killer- and killer-cell activity associated with increased polymorphonuclear leukocyte adherence in psoriasis

  • Original Contributions
  • Published:
Archives of Dermatological Research Aims and scope Submit manuscript

Summary

Patients (n=45) with psoriasis vulgaris were studied for natural killer (NK) cell activity and antibody-dependent cell cytotoxicity (ADCC) of their peripheral blood mononuclear cells against K-562 and L1210 target cells, respectively. Simultaneously, the studies were performed on the adherence to human endothelium of polymorphonuclear leukocytes (PMN) from various forms of the disease. Mean values of NK-cell activity in psoriasis vulgaris, as a whole, and mean values of ADCC in male patients were significantly lower than in a group of healthy controls. This decrease was most pronounced in patients with the active form of the disease, in whom in vitro PMN adherence to human endothelium was found to be increased. Neutrophils from both patients with active psoriasis and healthy individuals were capable of reducing NK-cell activity of normal human mononuclear cells.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Abb JH, Deinhardt F (1982) Effect of retinoic acid on the spontaneous and interferon-induced activity of human natural killer cells. Int J Cancer 30:307–310

    PubMed  Google Scholar 

  2. Acton FS (1959) Analysis of straight line data. John Wiley and Sons, New York

    Google Scholar 

  3. Bergstresser PR, Sedgwick JB, Hurd ER (1982) Neutrophil function in psoriasis: Increased adherence and enhanced superoxide generation. In: Beutner EH (ed) Autoimmunity in psoriasis, CRC Press, Boca Raton, Florida, pp 233–240

    Google Scholar 

  4. Bloom N, Minato N, Weighbour A, Reid L, Marcus D (1980) Interferon and NK cells in resistance to persistently virus-infected cells and tumors. In: Herberman RB (ed) Natural cell-mediated immunity against tumors. Academic Press, New York, pp 505–524

    Google Scholar 

  5. Bolhuis RLH (1980) Mechanisms of cytotoxicity by NK cells and their relationship to K cells. In: Herberman RN (ed) Natural cell-mediated immunity against tumors. Academic Press, New York, pp 289–294

    Google Scholar 

  6. Christophers E, Schroeder JM, Langner A (1982) Role of polymorphonuclear leukocyte chemotaxis in psoriasis. In: Beutner EH (ed) Autoimmunity in psoriasis. CRC Press, Boca Raton, pp 125–132

    Google Scholar 

  7. Clot J, Guilhou JJ, Andary M (1982) Immunological aspects of psoriasis. V. T-cell subsets and suppressor cell functions regulating immune responses in peripheral blood. J Invest Dermatol 78:313–315

    Article  PubMed  Google Scholar 

  8. Cormane RH, Hunyadi J, Hamerlinck F (1977) The role of lymphoid cells and polymorphonuclear leukocytes in the pathogenesis of psoriasis. In: Farber EH, Cox EJ (eds) Psoriasis: Proceedings of the second international symposium. Yorke Medical Books, New York, pp 47–54

    Google Scholar 

  9. Damerau B, Keller HU (1983) Comparison of adhesion to glass and aggregation of human leucocytes. Agents Actions 13:53–58

    PubMed  Google Scholar 

  10. Diaz-Perez JL, Goldyne ME, Winkelmann RK (1976) Prostaglandins and chemotaxis: Enhancement of polymorphonuclear leukocyte chemotaxis by prostaglandin F2. J Invest Dermatol 66:149–151

    Article  PubMed  Google Scholar 

  11. Ewan PW, Barrett HM, Pusey CD (1983) Defective natural killer (NK) and killer (K) cell function in systemic lupus erythematosus. J Clin Lab Immunol 10:71–76

    PubMed  Google Scholar 

  12. Flad HD, Betzler M, Scholz W, Schlag P, Schreml W, Herfarth CH (1982) Modulation of NK cell activity in patients with solid malignancies by surgical tumor reduction and fibroblast interferon. In: Serron B (ed) Human cancer Immunology, vol 7. Elsevier North Holland, Amsterdam, pp 195–204

    Google Scholar 

  13. Fehr J, Jacob HS (1977) In vitro granulocyte adherence and in vivo margination: Two associated complement-dependent functions. Studies based on the acute neutropenia of filtration leukopheresis. J Exp Med 146:641–647

    Article  PubMed  Google Scholar 

  14. Gladman DD, Keystone EC, Schachter RK (1983) Aberrations in T-cell subpopulations in patients with psoriasis and psoriatic arthritis. J Invest Dermatol 80:286–290

    Article  PubMed  Google Scholar 

  15. Gliński W (1982) Cellular factors in psoriasis and their interaction with humoral factors. In: Beutner EH (ed) Autoimmunity in psoriasis. CRC Press, Boca Raton, Florida, pp 205–218

    Google Scholar 

  16. Gliński W, Jabŀońska S, Zarebska Z, Beutner EH, Jarząbek-Chorzelska M (1982) Role of blood-borne factors in psoriasis. In: Marks E, Christophers E (eds) The epidermis in disease. MTP Press, Lancester, pp 371–380

    Google Scholar 

  17. Gliński W, Obaŀek S, Langner A, Jabŀońska S, Haftek M (1978) Defective function of T lymphocytes in psoriasis. J Invest Dermatol 70:105–110

    PubMed  Google Scholar 

  18. Goetzl EJ, Brindley LL, Goldman DW (1983) Enhancement of human neutrophil adherence by synthetic leukotriene constituents of the slow-reacting substance of anaphylaxis. Immunology 50:35–41

    PubMed  Google Scholar 

  19. Henson PM (1971) The immunologic release of constituents from neutrophil leucocytes. I. The role of antibody and complement on nonphagocytic surfaces or phagocytic particles. J Immunol 107:1535–1538

    PubMed  Google Scholar 

  20. Herberman RB (1982) Natural killer cells and their possible relevance to transplantation biology. Transplantation 34:1–7

    PubMed  Google Scholar 

  21. Herberman RB, Djeu JY, Kay HD, Ortaldo JR, Riccardi C, Bonnard GD, Holden HT, Fagnani R, Santoni A, Puccetti P (1979) Natural killer cells: Characteristics and regulation of activity. Immunol Rev 44:43–70

    PubMed  Google Scholar 

  22. Herlin T, Borregaard N, Kragballe K (1982) On the mechanisms of enhanced monocyte and neutrophil cytotoxicity in severe psoriasis. J Invest Dermatol 79:104–108

    Article  PubMed  Google Scholar 

  23. Hunyadi J, Dobozy A, Kenderessy AS, Simon N (1980) Suppressor function of peripheral blood mononuclear cells in patients with psoriasis vulgaris. J Invest Dermatol 75:217–218

    Article  PubMed  Google Scholar 

  24. Jabŀońska S, Beutner EH, Jarząbek-Chorzelska M, Rzęsa G, Maciejowska E, Chowaniec O, Chorzelski T (1979) Clinical significance of autoimmunity in psoriasis. In: Milgram F, Albini B (eds) Immunopathology. Karger, Basel, pp 148–153

    Google Scholar 

  25. Jabŀońska S, Gliński W, Beutner EH (1982) Survey of immunological influences in psoriasis. In: Farber EM, Cox AJ, Nalli L, Jacobs PH (eds) Psoriasis. Grune and Stratton, New York, pp 89–96

    Google Scholar 

  26. Jaffe EA (1980) Culture of human endothelial cells. Transplant Proc (Suppl) 1:49–53

    Google Scholar 

  27. Kamiński MJ, Nowaczyk M, Skopińska-Różewska E, Bem W (1981) Human peripheral blood lymphocyte subpopulations isolated on the basis of their affinity for SRBC differ in angiogenesis-inducing capability. Clin Exp Immunol 46:327–331

    PubMed  Google Scholar 

  28. Kamiński M, Szmurŀo A, Pawińska M, Jabŀońska S (1984) Decreased natural killer cell activity in psoriasis pustulosa (von Zumbusch type). Br J Dermatol 110:565–568

    PubMed  Google Scholar 

  29. Katz P, Zaytoun AM, Lee JH Jr, Panush RS, Longley S (1982) Abnormal natural killer cell activity in systemic lupus erythematosus: An intrinsic defect in the lytic event. J Immunol 129:1966–1971

    PubMed  Google Scholar 

  30. Kay HD, Smith DL (1983) Regulation of human lymphocyte-mediated natural killer (NK) cell activity. I. Inhibition in vitro by peripheral blood granulocytes. J Immunol 130:475–483

    PubMed  Google Scholar 

  31. Kovithavongs T, Hottman WC, Dossetor JB (1974) Effector cell activity in antibody-mediated cell-dependent immune lympholysis. I. Normal individuals. J Immunol 113:1178–1181

    PubMed  Google Scholar 

  32. Krueger G, Jederberg WW (1982) Mononuclear cell function and its relative potential in the pathogenesis of psoriasis. In: Beutner EH (ed) Autoimmunity in psoriasis. CRC Press, Boca Raton, Florida, pp 183–204

    Google Scholar 

  33. Langner A, Chorzelski T, Frączykowska M, Jabŀońska S, Szymańczyk (1983) Is polymorphonuclear chemotaxis increased in psoriasis? Arch Dermatol Res 275:226–228

    PubMed  Google Scholar 

  34. Ligresti DJ, Neft JC, Lowney ED (1982) Increased helpersuppressor T-cell ratio in psoriasis. Arch Dermatol 118:966–970

    Article  PubMed  Google Scholar 

  35. Majewski S, Jabŀonska S, Langner A, Pawińska M, Szmurŀo A (1985) Adherence to human endothelium and plastic of neutrophils from patients with psoriasis and effects of psoriatic sera on normal neutrophils. Br J Dermatol 112:655–662

    PubMed  Google Scholar 

  36. Malmsten CL, Palmblad J, Uden AM, Radmark O, Engstedt L, Samuelsson B (1980) Leukotriene B: A highly potent and stereospecific factor stimulating margination of polymorphonuclear leukocytes. Acta Physiol Scand 110:449–452

    PubMed  Google Scholar 

  37. Pacześniak J, Tchórzewski H (1983) The effect of polymorphonuclear leukocyte (PMNL) factor on human natural killer (NK) cell activity in vitro. Acta Physiol Pol 34:214–226

    Google Scholar 

  38. Sauder SN, Bailin PL, Saundeen J, Krakauer RS (1980) Suppressor cell function in psoriasis. Arch Dermatol 116:51–55

    Article  PubMed  Google Scholar 

  39. Sedgwick JB, Bergstresser PR, Hurd ER (1980) Increased granulocyte adherence in psoriasis and psoriatic arthritis. J Invest Dermatol 74:81–84

    Google Scholar 

  40. Spagnuolo PJ, Lederman MM, Schlitz J, Ellner J, Culp L (1982) A possible role for cold insoluble globulin in chemotactic factor mediated polymorphonuclear leukocyte adherence to plastic. Biochem Biophys Res Commun 106:471–478

    PubMed  Google Scholar 

  41. Stern R, Tierler S, Parrish P (1982) Psoriasis and the risk of cancer. J Invest Dermatol 78:147–149

    PubMed  Google Scholar 

  42. Tchórzewski H, Suŀkowska Z, Zeman K (1984) Modulation of immune response in vitro and in vivo by human granulocyte factors. Immunol Lett 8:187–195

    Article  PubMed  Google Scholar 

  43. Tilden AB, Abo T, Balch CM (1983) Suppressor cell function of human granular lymphocytes identified by the HNK-1 (LEU 7) monoclonal antibody. J Immunol 130:1171–1175

    PubMed  Google Scholar 

  44. Tsokos GG, Rook AH, Djeu JY, Balow JE (1982) Natural killer cells and interferon responses in patients with systemic lupus erythematosus. Clin Exp Immunol 50:239–245

    PubMed  Google Scholar 

  45. Wahba A, Cohen HA, Bar-Eli M, Gallily R (1978) Enhanced chemotactic and phagocytic activities of leukocytes in psoriasis vulgaris. J Invest Dermatol 71:186–188

    Article  PubMed  Google Scholar 

  46. Wąsik M, Gradowska L, Rowińska D, Lao M, Orŀowski T (1981) Diagnostic and prognostic value of antibody-dependent cellular cytotoxicity and lectin-induced cellular cytotoxicity tests for renal graft rejection. Transplantation 32:217–221

    PubMed  Google Scholar 

  47. Wright JK, Hughes P, Rowell NR (1982) Spontaneous lymphocyte-mediated (NK cell) cytotoxicity in systemic sclerosis: A comparison with antibody-dependent lymphocyte (K cell) cytotoxicity. Ann Rheum Dis 41:409–413

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Dermatology, Warsaw School of Medicine, Koszykowa 82 A, 02-008, Warsaw, Poland

    S. Majewski, S. Jabŀońska, M. Kamiński & M. Frączykowska

  2. Transplantation Institute, Warsaw School of Medicine, Warsaw, Poland

    M. Wąsik

Authors
  1. S. Majewski
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Wąsik
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. Jabŀońska
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. Kamiński
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M. Frączykowska
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Majewski, S., Wąsik, M., Jabŀońska, S. et al. Defective natural-killer- and killer-cell activity associated with increased polymorphonuclear leukocyte adherence in psoriasis. Arch Dermatol Res 278, 264–269 (1986). https://doi.org/10.1007/BF00407735

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00407735

Key words

Search

Navigation