Summary
Various subtypes of 17 European nasopharyngeal carcinomas are examined by immunocytological and immunohistological methods. The T-and B-Cells in the inflammatory infiltrate are determined quantitatively and correlated with the amount and type of intracellular immunoglobulin. This data is compared with peripheral T-Cell values and the serum anti Epstein-Barr virus (EBV) titers, and finally with the tumor type and stage. Three of the 17 patients had marked local immunoglobulin producing cells, 8 only moderate, and 6 had nearly none. The intracellular immunoglobulin was primarily IgG/k, and no significant increase of IgA producing cells was observed as suggested by others. No clearcut correlation was found between local T-and B-Cell infiltrates and the tumor type, stage of disease or anti EBV titers in the patients' serum. The possible implication of this data is discussed.
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Supported by research grants to G.R.F.K. by Germany Science Foundation and by the State Ministry of Science and Research of Northrhine-Westfalia
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Konorza, G., Sesterhenn, K., Krueger, G.R.F. et al. Distribution of T-and B-cells and of immunoglobulin-producing cells in tumor tissue of patients with nasopharyngeal carcinoma. J Cancer Res Clin Oncol 93, 195–204 (1979). https://doi.org/10.1007/BF00406578
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DOI: https://doi.org/10.1007/BF00406578