Summary
The spontaneous nitro-blue tetrazolium (NBT) reduction of monocytes from patients with gastric cancer was assessed and compared with an in vitro monocyte-mediated cytostasis of tumor cell lines and their suppressor activity. The increased NBT reduction correlated with the ability of monocytes to inhibit mitogen-induced normal lymphocyte response and cytostatic activity against L-1210 murine lymphoma cell line. These observations suggest that “activated” monocytes of some cancer patients may play the role of suppressor cells and exert an anti-tumor effect in vitro.
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Abbreviations
- AC:
-
adherent cells
- ADCC:
-
antibody-dependent cellular cytotoxicity
- NBT:
-
nitroblue tetrazolium
- EAhu-RFC:
-
cells forming rosettes with antibody-coated human erythrocytes
- PBM:
-
peripheral blood mononuclear cells
- SPS:
-
stimulation of protein synthesis
- PHA:
-
phytohaemagglutinin
- FCS:
-
foetal calf serum
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Uracz, W., Mytar, B., Zembala, M. et al. “Activated” monocytes in gastric cancer patients. J Cancer Res Clin Oncol 104, 307–313 (1982). https://doi.org/10.1007/BF00406249
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DOI: https://doi.org/10.1007/BF00406249