Summary
Post-shift and next-morning urine was sampled from workers exposed to hexahydrophtalic anhydride (HHPA), an epoxy hardener, sensitising at low exposure levels. Exposure levels of HHPA in air gas chromatography, GC) in the range of 30–270 μg/m3 corresponded to urinary concentrations of 0.9–2.8 μmol hexahydrophthalic acid (HHP acid; GC-mass spectrometry)/mmol creatinine. In the morning samples the concentrations were <0.04-0.3 μmol HHP acid/mmol creatinine. In unexposed controls, the level was <0.1 μmol/mmol creatinine. A correlation was found between the time-weighted levels of HHPA in air and HHP acid in the post-shift urine (r s = 0.93; P < 0.023), indicating that the determination of HHP acid in urine is suitable for biologic monitoring of HHPA exposure.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Moller DR, Gallagher JS, Bernstein DI, Wilcox TG, Burroughs HE, Bernstein IL (1985) Detection of IgE mediated respiratory sensitization in workers exposed to hexahydrophthalic anhydride. J Allergy Clin Immunol 75:663–672
Päffli P (1986) Phthalic acid excretion as an indicator of exposure to phthalic anhydride in the work atmosphere. Int Arch Occup Environ Health 58:209–216
Pfäffli P, Savolainen H, Keskinen H (1989) Determination of carboxylic acids in biological samples as their trichloroethyl esters by gas chromatography. Chromatographia 17:483–488
Savolainen H, Pfäffli P (1986) Biochemical effects and monitoring of exposure of rats to 4-methylcyclohexyl-1,6-dicarboxylic acid anhydride vapour. Acta Pharmacol Toxicol 59:209–213
Venables KM (1989) Low molecular weight chemicals, hypersensitivity, and direct toxicity: the acid anhydrides. Br J Ind Med 46:222–232
Welinder H, Nielsen J, Gustavsson C, Bensryd I, Skerfving S (1990) Specific antibodies to methyltetrahydrophthalic anhydride in exposed workers. Clin Exp Allergy 20:639–645
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Jönsson, B., Welinder, H. & Skarping, G. Hexahydrophthalic acid in urine as an index of exposure to hexahydrophthalic anhydride. Int. Arch Occup Environ Heath 63, 77–79 (1991). https://doi.org/10.1007/BF00406202
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00406202