Summary
Immunological and respiratory findings were studied in a group of 19 male soybean workers. Twenty control workers also participated in the immunological studies. All soybean workers had positive immediate skin reactions to soybean extract, as did 19/20 control workers. Similarly, 18/19 soy workers reacted to soy antigen prepared after separation from oil, but only 3/19 to soy lecithin antigen and 1 to soy oil antigen. A majority of soy workers (13/19) reacted to house dust. Only 3/19 soy workers had increased levels of soy-specific IgE. The prevalence of chronic respiratory symptoms was higher in exposed than in control workers, being significantly different for dyspnea (P < 0.01). Workers with increased specific serum IgE or positive skin tests to house dust did not have any more symptoms than workers with negative tests. Ventilatory function was significantly worse in soybean workers than expected. Nevertheless, workers with positive skin or serological tests to house dust had across-shift changes similar to those with negative tests. These data suggest that skin and airway responses to soybean components (particularly the non-lipid ones) are very frequent among soybean workers. In the current study specific (soy) and non-specific (house dust) skin tests and immunoglobulins did not allow us to identify the workers at risk of developing symptoms or lung function abnormalities. This suggests that in addition to any atopic mechanisms, the irritant effect of soy dust may play a role in this occupational airway disease.
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References
Bush RK, Cohen M (1977) Immediate and late onset asthma from occupational exposure to soybean dust. Clin Allergy 7:369–373
Bush RK, Taylor SL, Nordlee JA, Busse WW (1985) Soybean oil is not allergenic to soybean sensitive individuals. J Allergy Clin Immunol 76:242–245
Cherniack RM, Raber MB (1972) Normal standards for ventilatory function using an automated wedge spirometer. Am Rev Resp Dis 106:38–46
Commission des Communautes Européennes, CECA (1971) Aide mémoire pour la pratique de l'examen de la fonction ventilatoire par la spirographie. Collection d'Hygiène et de Médecine du Travail, Luxembourgh, no. 11
Committee on Skin Test Standardization of The Netherlands Society of Allergology (1988) Report on skin test standardization. Clin Allergol 18:305–310
Dahl R, Zetterstrom O (1987) The effect of orally administered sodium cromoglycate on allergic reactions caused by food allergens. Clin Allergy 8:419–422
Duke WW (1934) Soybean as a possible important source of allergy. Allergy 5:300–302
Edsley F (1982) Allergy to soybean investigated by crossed radioiummunoelectrophoresis (CRIE). XIth International Congress on Allergology and Clinical Immunology, London, abstract no. PB54
Goodwin BFJ (1982) IgE antibody levels to investigate soya protein determined in normal adult population. Clin Allergy 12:55–62
Johansson SGO (1968) Serum IgND levels in healthy children and adults. Intern Arch Allergy 34:1–4
Kuisu S, Lenz D, Bessot JC, Pauli G (1980) Rhinite allergiques professionnelle par exposition à la poudre de soja. Rev Franc Allerg 20:75–77
Medical Research Council Committee on the Aetiology of Chronic Bronchitis (1960) Standardized questionnaire on respiratory symptoms. Br Med J 2:1665
Olsen AM, Prickman LE (1936) Hypersensitivity to soy beans. Proc Meet Mayo Clin 11:465–468
Pauli G, Bessot JC, Kopferschmitt MC, Lingot G, Mendling R, Ducos P, Limasset JC (1980) Meat wrapper's asthma. Identification of the causal agent. Clin Allergy 10:263–269
Peters GA (1965) Bronchial asthma due to soybean allergy: report on case with audiovisual documentation. Ann Allergy 23:270–272
Porras O, Carlsson B, Falstrom SP, Hanson LA (1985) Detection of soy protein in soy cecithin, margarine, and occasionally soy oil. Int Arch Allergy Appl Immunol 78:30–32
Rodrigo MJ, Morell F, Helm RM, Swanson M, Greife A, Anto JM, Sunyer J, Reed CE (1990) Identification and partial characterization of the soybean-dust allergens involved in the Barcelona asthma epidemic. J Allergy Clin Immunol 85:778–784
Sepulveda R, Rivera S (1982) Clinical and immunological follow-up of workers exposed to soybean flour. XIth International Congress on Allergy and Clinical Immunology, London, abstract no. 450
Sheldon JM, Lowell RG, Mathews KP (1967) A manual of clinical allergy. Saunders, Philadelphia London, pp 507–531
Shibasaki M, Suzuki S, Tajima S, Nemoto H, Kuroume T (1980) Allergenicity of major component proteins of soybean. Int Arch Allergy Appl Immunol 61:441–448
Sunyer J, Anto JM, Rodrigo MJ, Morell (1989) Case control study of serum immunoglobulin-E antibodies reactive with soybean in epidemic asthma Lancet I:179–182
Wightman HB (1938) Soybean sensitivity with a case report. J Allergy 9:601–603
World Health Organization (1986) Early detection of occupational diseases, WHO, Geneva, pp 145–190
Zafiropoulo A, Blanc M (1961) Une cause rare d'asthme: l'allergie au sojy. Réunion de pneumo-phtisiologiedu sud-est et du littoral méditerranéen, Novembre 11
Zuskin E, Skuric Z (1984) Respiratory function in tea workers. Br J Ind Med 41:88–93
Zuskin E, Valic F, Skuric Z (1979) Respiratory function in coffee workers. Br J Ind Med 36:117–122
Zuskin E, Skuric Z, Kanceljak B, Pokrajac D, Schachter EN, Witek TJ (1988) Respiratory symptoms and ventilatory capacity in soybean workers. Am J Ind Med 14:157–165
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Zuskin, E., Kanceljak, B., Schachter, E.N. et al. Immunological and respiratory changes in soy bean workers. Int. Arch Occup Environ Heath 63, 15–20 (1991). https://doi.org/10.1007/BF00406192
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DOI: https://doi.org/10.1007/BF00406192