Summary
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1.
A careful replication of the Minz and Walaszek test failed to demonstrate its reliability as a clinical tool for diagnosing schizophrenia.
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2.
Human serum contains substances toxic to rabbits. There is some indication that schizophrenic serum has greater toxicity than nonschizophrenic sera.
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3.
Local application of a 5% epinephrine solution to the cerebral cortex causes a rise in blood pressure in about half the rabbits treated with normal serum.
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4.
Effects of some tests with psychoactive drugs on the local epinephrine responses are reported.
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Supported by United States Public Health Service grants MY-1971 and MY-1972, R. W. Gerard, M.D., Ph.D. Principal Investigator.
With technical assistance of Neil V. Williams.
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Fujita, S., Rosenzweig, N. Use of the cortical epinephrine pressor response in rabbits as a diagnostic test for schizophrenia. Psychopharmacologia 4, 367–376 (1963). https://doi.org/10.1007/BF00405247
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DOI: https://doi.org/10.1007/BF00405247