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Chlordiazepoxide and conditioned suppression

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Summary

Chlordiazepoxide (12 mg/kg) reduced the suppressive effects of a CER stimulus if the drug was given prior to CS-shock pairings. No attenuation of suppression occurred if the drug was given prior to the test for suppressive effects of the CS. This attenuating effect of chlordiazepoxide upon CER learning occurred if the behavior suppressed by the CS was either milk licking or lever pressing for food. The effect was dose-related with higher dosages causing a greater attenuation of CER learning.

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Authors and Affiliations

  1. Dept. of Psychology, Princeton University, USA

    Stanley R. Scobie

  2. Lakeside Laboratories, Milwaukee, Wisconsin

    George Garske

Authors
  1. Stanley R. Scobie
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  2. George Garske
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Additional information

Preliminary parts of this research were performed while the first author was at Lakeside Laboratories, Milwaukee, Wisconsin.

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Scobie, S.R., Garske, G. Chlordiazepoxide and conditioned suppression. Psychopharmacologia 16, 272–280 (1970). https://doi.org/10.1007/BF00404733

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  • DOI: https://doi.org/10.1007/BF00404733

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