Summary
Several previous studies have demonstrated a chemotactic factor for white blood cells in extracts from psoriatic scales. In the present work, the question was studied whether chemotaxis is a primary or a secondary event in the development of a psoriatic lesion. The migration-stimulating properties of polymorphonuclear leukocytes of different extracts were determined by means of a modified Boyden technique. Aqueous extracts of psoriatic scales were good stimulators of migration of both autologous and homologous leukocytes. Uninvolved skin adjacent to psoriatic plaques (perilesional skin) has previously been shown to differ from control skin in various respects. Extracts of such perilesional skin of psoriatic patients did not have migration-stimulating properties. This result indicates that chemotaxis is a secondary event in the pathogenesis of psoriasis.
Zusammenfassung
Frühere Untersuchungen haben gezeigt, daß Extrakte von Psoriasisschuppen leukocytenchemotaktische Wirkung besitzen. In dieser Arbeit wurde die Frage studiert, ob Chemotaxis ein primäres oder ein sekundäres Geschehen in der Entwicklung eines Psoriasisherd ist. Die migrationsstimulierenden Eigenschaften polymorphkerniger Leukocyten sind mittels einer modifizierten Boyden-Technik für verschiedene Extrakte untersucht worden. Wäßrige Extrakte von Psoriasisschuppen waren gute Stimulatoren der Migration von autologen und homologen Leukocyten. Die unbefallene Haut in der Nähe von Psoriasisherden (periläsionale Haut) besitzt viele abnorme Eigenschaften, obgleich sie keine klinisch sichtbaren Veränderungen aufweist. Extrakte von periläsionaler Haut weisen keine migrationsstimulierende Wirkung auf. Diese Resultate sprechen dafür, daß Chemotaxis ein sekundäres Phänomen in der Pathogenese der psoriatischen Hautveränderungen ist.
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Lidén, S., Bäck, O. & Pettersson, A. Migration-stimulating effect of psoriatic scales on polymorphonuclear leukocytes. Arch Dermatol Res 269, 93–98 (1980). https://doi.org/10.1007/BF00404463
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DOI: https://doi.org/10.1007/BF00404463