Summary
The cytotoxic effect of bleomycin and peplomycin was compared using a methylcellulose monolayer assay for the cultivation of human tumor cells. In 3 out of 4 samples from human malignant melanomas peplomycin proved to be more cytotoxic than bleomycin. Peplomycin was more cytotoxic than bleomycin in 1 of 5 myosarcoma samples, whereas 2 samples from squamous cell carcinomas of the lung showed identical dose response curves. In 1 carcinoma of the gall bladder peplomycin was more toxic than bleomycin.
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Supported by Bundesministerium für Jugend, Familie und Gesundheit, Bonn
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Neumann, H.A., Runge, H.M., Fiebig, H.H. et al. Comparison of bleomycin and peplomycin toxicity on clonogenic tumor cells from various human tumors. J Cancer Res Clin Oncol 112, 165–169 (1986). https://doi.org/10.1007/BF00404401
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DOI: https://doi.org/10.1007/BF00404401