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An analysis of dopa-induced locomotor stimulation in mice with inhibited extracerebral decarboxylase

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Abstract

The effect of different drugs and chemical substances on the strong locomotor stimulation or slight hyperactivity induced by 150 or 100 mg/kg of 3,4-dihydroxyphenylalanine, respectively, in mice pretreated with seryl-trihydroxy benzyl-hydrazine, an inhibitor of extracerebral decarboxylase has been investigated. Our results suggest the importance of catecholamines for behavioral stimulation induced in this way and do not confirm the hypothesis proposed by Scheckel et al. (1969) based on conditioned avoidance procedures in rats. The role of dopamine, noradrenaline and 5-hydroxytryptamine is also discussed.

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Authors and Affiliations

  1. Department of Pharmacology, School of Medicine, Lublin, Poland

    Edmund Przegaliński & Zdzisław Kleinrok

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  1. Edmund Przegaliński
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  2. Zdzisław Kleinrok
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Przegaliński, E., Kleinrok, Z. An analysis of dopa-induced locomotor stimulation in mice with inhibited extracerebral decarboxylase. Psychopharmacologia 23, 279–288 (1972). https://doi.org/10.1007/BF00404133

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  • DOI: https://doi.org/10.1007/BF00404133

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