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Role of the tuberculum olfactorium in stereotyped behaviour induced by apomorphine in the rat

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Abstract

Bilateral ablation of the tuberculum olfactorium markedly reduced stereotyped behaviour following apomorphine treatment in the rat. Bilateral dissection of the olfactory bulb or large bilateral lesions in the nucleus caudatus putamen did not significantly affect the stereotyped behaviour. It is concluded that an intact tuberculum olfactorium is essential for the induction of stereotyped behaviour by apomorphine.

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References

  • Adey, R.: The sense of smell. In: Handbook of Physiology, J. Field, H. W. Magoun and V. E. Hall, eds. Sect. 1, Vol.1. Washington: American Physiology Society 1959.

    Google Scholar 

  • Andén, N.-E., Fuxe, K., Hamburger, B., Hokfelt, T.: A quantitative study on the nigro-neostriatal dopamine neuron system in the rat. Acta physiol. scand. 67, 306–312 (1966).

    Google Scholar 

  • — Rubenson, A., Fuxe, K., Hokfelt, T.: Evidence for dopamine receptor stimulation by apomorphine. J. Pharm. Pharmacol. 19, 627–629 (1967).

    Google Scholar 

  • Barnett, S. A.: The rat: A study in behaviour, pp. 34–80. Chicago: Aldine 1963.

    Google Scholar 

  • Butcher, L. L., Andén, N.-E.: Effects of apomorphine and amphetamine on schedule-controlled behaviour: reversal of tetrabenazine suppression and dopaminergic correlates. Europ. J. Pharmacol. 6, 255–264 (1969).

    Google Scholar 

  • Da Prada, M., Pletscher, A.: Acceleration of the cerebral dopamine turnover by chlorpromazine. Experientia (Basel) 22, 465–466 (1966).

    Google Scholar 

  • Ernst, A. M.: Relation between the action of dopamine and apomorphine and their o-methylated derivatives upon the CNS. Psychopharmacologia (Berl.) 7, 391–399 (1965).

    Google Scholar 

  • —: Mode of action of apomorphine and dexamphetamine on gnawing compulsion in rats. Psychopharmacologia (Berl.) 10, 316–323 (1967).

    Google Scholar 

  • —: The role of biogenic amines in the extrapyramidal system. Acta physiol. pharmacol. neerl. 15, 141–154 (1969).

    Google Scholar 

  • —, Smelik, P. G.: Site of action of dopamine and apomorphine on compulsive gnawing behaviour in rats. Experientia (Basel) 22, 837–838 (1966).

    Google Scholar 

  • Fuxe, K.: The distribution of monoamine terminals in the central nervous system. Acta physiol. scand. 64, Suppl. 247, 37–85 (1965).

    Google Scholar 

  • Massopust, L. C.: Stereotaxic atlas of the diencephalon of the albino rat. Laboratory of Neuronanatomical Sciences. N. I. H., Bethesda, Maryland.

  • Roos, B.-E.: Decrease in homovanillic acid as evidence for dopamine receptor stimulation by apomorphine in the neostriatum of the rat. J. Pharm. Pharmacol. 21, 263–264 (1969).

    Google Scholar 

  • Rossum, J. M. van: The significance of dopamine-receptor blockade for the mechanism of action of neuroleptic drugs. Arch. int. Pharmacodyn. 160, 492–494 (1966).

    Google Scholar 

  • Ther, L., Schramm, H.: Apomorphine-Synergismus (Zwangsnagen bei Mäusen) als Test zur Differenzierung psychotroper Substanzen. Arch. int. Pharmacodyn. 138, 302–310 (1962).

    Google Scholar 

  • Ungerstedt, U., Butcher, L. L., Butcher, S. G., Andén, N.-E., Fuxe, K.: Direct chemical stimulation of dopaminergic mechanisms in the neostriatum of the rat. Brain Res. 14, 461–471 (1969).

    Google Scholar 

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McKenzie, G.M. Role of the tuberculum olfactorium in stereotyped behaviour induced by apomorphine in the rat. Psychopharmacologia 23, 212–219 (1972). https://doi.org/10.1007/BF00404127

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  • DOI: https://doi.org/10.1007/BF00404127

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