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The effect of monoamine oxidase inhibitors on the deconditioning action of reserpine in rats

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Summary

The effects of two different dosage schedules of reserpine and pretreatment with inhibitors of monoamine oxidase were studied on rats conditioned to the “barrier-crossing response” in the Warner cage.

Reserpine provoked a gradual deconditioning when it was administered in small and repeated doses; with a single high dose, the deconditioning was abrupt.

Pheniprazine, nialamid and I.S. 2596 (N′-(1,4-ben odioxan-2-methyl)-N′-benzylhydrazine) were capable of preventing the deconditioning effect of reserpine.

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Authors and Affiliations

  1. Laboratory of Therapeutic Chemistry, Istituto Superiore di Sanità, Rome, Italy

    Otto A. Orsingher

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  1. Otto A. Orsingher
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Orsingher, O.A. The effect of monoamine oxidase inhibitors on the deconditioning action of reserpine in rats. Psychopharmacologia 2, 326–333 (1961). https://doi.org/10.1007/BF00404120

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  • DOI: https://doi.org/10.1007/BF00404120

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