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Urinary excretion of perphenazine and its sulfoxide during administration in oral and long-acting injectable form

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  • Human Pharmacology
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Abstract

Urinary excretion of the unchanged drug and perphenazine-sulfoxide was measured in a group of patients receiving at first oral perphenazine (24 mg dd) and after some weeks perphenazine-enanthate, a long-acting injectable preparation (100 mg per 14 days). A significant decrease in the absolute quantities of unchanged perphenazine and of the sulfoxide was observed. There was no constant ratio between the quantities excreted. A relative increase in the excretion, expressed in percentages of the administrated dose, was demonstrated.

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Authors and Affiliations

  1. Biochemical Laboratory, Mental Hospital Endegeest, Oegstgeest, The Netherlands

    G. M. J. van Kempen

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  1. G. M. J. van Kempen
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Additional information

The author wishes to express his gratitude to W. De Waard, psychiatrist, who supervised the clinical trial in this Hospital, for his cooperation and Miss M. Potman, Mr. R. Van Elk and Mr. A. Van de Weerthof for their technical assistance.

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van Kempen, G.M.J. Urinary excretion of perphenazine and its sulfoxide during administration in oral and long-acting injectable form. Psychopharmacologia 21, 283–286 (1971). https://doi.org/10.1007/BF00403866

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  • DOI: https://doi.org/10.1007/BF00403866

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