Abstract
In this self-experiment, conducted under double-blind conditions using several psychological tests to assess drug effects, it was found that the pre-treatment with 2,4,5-trimethoxyphenylethylamine potentiates the effects of mescaline (3,4,5-trimethoxyphenylethylamine).
2,4,5-trimethoxyphenylethylamine alone proved to have no psychotomimetic properties.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Balestrieri, A.: Patologia mentale e farmacologia. Padova: Cedam 1961.
Bellak, L., Chassan, J. B.: An approach to the evaluation of drug effect during psychotherapy: a double-blind study of a single case. J. nerv. ment. Dis. 139, 20–30 (1964).
Brickenkamp, R.: Test d2 — Aufmerksamkeits Belastungstest Handanweisung, 2. Aufl. Göttingen: Hogrefe 1967.
Clark, L. D., Bliss, E. L.: Psychopharmacological studies of LSD-25 intoxication. Arch. Keurol. Psychiat. (Chic.) 81, 348–359 (1959).
—, Nakashima, E. N.: Experimental studies of marihuana. Amer. J. Psychiat. 125, 379–384 (1968).
Chassan, J. B.: Statistical inference and the single case in clinical design. Psychiatry 23, 173–184 (1960).
Deniker, P. J.: Biological changes in man following intravenous administration of mescaline. J. nerv. ment. Dis. 125, 427–431 (1957).
Heimann, H.: Ausdrucksphänomenologie der Modellpsychosen (Psilocybin). Psychiat. et Neurol. (Basel) 141, 69–100 (1961).
—: Essai d'objectivation expérimentale et clinique de l'émotionnalité. Schweiz. Arch. Neurol. Neurochir. Psychiat. 100, 475–486 (1967).
- Personal communication (1970).
Hoffer, A., Osmond, H.: The hallucinogens. New York: Academic Press 1967.
Jones, R. T., Stone, G. C.: Psychological studies of marihuana and alcohol in man. Psychopharmacologia (Berl.) 18, 108–117 (1970).
Kristof, W.: Eine Faktorenanalyse geometrisch-optischer Täuschungen. Z. exp. angew. Psychol. 10, 583–596 (1963).
Meldman, M. J.: The quantitative analysis of anxiety and depression. Psychosomatics 6, 8–15 (1965).
Obermair, W.: Personal communication (1970).
Smythies, J. R., Benington, F., Morin, R. D., Clark, L. C.: Structure-activity relationship studies on mescaline. III. The influence of the methoxy groups. Psychopharmacologia (Berl.) 10, 379–387 (1967a).
—, Johnston, V. S., Bradley, R. J.: Alteration by pretreatment with iproniazid and an inactive mescaline analogue of a behaviour change by mescaline. Nature (Lond.) 216, 196–197 (1967b).
Theobald, W., Buech, O., Kunz, H. A., Krupp, P., Stenger, E. G., Heimann, H.: Pharmakologische und experimentalpsychologische Untersuchungen mit 2 Inhaltsstoffen des Fliegenpilzes (Amanita Muscaria). Arzneimittel-Forsch. (Drug Res.) 18, 311–315 (1968).
Wikler, A.: Clinical and electroencephalographic studies on the effects of mescaline, N-allylnormorphine and morphine in man. J. nerv. ment. Dis. 120, 157–175 (1954).
Wolbach, A. B., Isbell, H., Miner, E. J.: Cross tolerance between mescaline and LSD-25. With a comparison of the mescaline and LSD reactions. Psychopharmacologia (Berl.) 3, 1–14 (1962).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Dittrich, A. Alteration of behavioural changes induced by 3,4,5-trimethoxyphenylethylamine (mescaline) by pretreatment with 2,4,5-trimethoxyphenylethylamine. Psychopharmacologia 21, 229–237 (1971). https://doi.org/10.1007/BF00403861
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00403861