Abstract
Five experiments were conducted in order to assess the effects of monoamine oxidase inhibitors on the copulatory behavior of male rats. Copulatory behavior was studied after administration of a) three injections of 25 mg/kg iproniazid, b) single injections of 50 and 100 nig/kg iproniazid, c) single injections of 50 and 100 mg/kg nialamide, and d) single injections of 25 and 50 mg/kg pargyline. All treatments produced some retardation of copulatory behavior, although not all measures were affected by all drugs. A total of 21 statistically significant effects appeared. All were in the direction of retardation. Results are consistent with the hypothesis that high brain monoamine levels inhibit copulatory behavior in male rats.
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Supported by Grants GB-6590 and GB-12941 from the National Science Foundation. H. N. D. was supported by a traineeship from the Center for Neurobiological Sciences. Hormones were provided through the courtesy of Dr. Preston L. Perlman of the Schering Corporation, Bloomfield, New Jersey. Iproniazid phosphate (Marsilid) was provided through the courtesy of Hoffmann-La Roche Inc. Nialamide (Niamid) was provided through the courtesy of Pfizer Laboratories Division. Pargyline HCl (Eutonyl) was provided through the courtesy of Abbott Laboratories.
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Dewsbury, D.A., Davis, H.N. & Jansen, P.E. Effects of monoamine oxidase inhibitors on the copulatory behavior of male rats. Psychopharmacologia 24, 209–217 (1972). https://doi.org/10.1007/BF00403640
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DOI: https://doi.org/10.1007/BF00403640