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Psychopharmacologia

, Volume 7, Issue 6, pp 391–399 | Cite as

Relation between the action of dopamine and apomorphine and their O-methylated derivatives upon the CNS

  • A. M. Ernst
Original Investigations

Summary

The syndrome of gnaw-compulsion was studied in rats providing evidence for a structure-effect relationship between the alcaloid apomorphine and the normal metabolite in the brain, dopamine.

The following tentative conclusions could be drawn from the available data:
  1. 1.

    The phenylethylamine-configuration with an OH-group at the para-position or at both the para- and meta-positions of the phenolring is essential for provoking a gnaw-compulsion syndrome;

     
  2. 2.

    Replacement of the OH-group at the para-position or at both the para- and meta-position by an OCH3-group antagonizes this effect and induces a hypokinetic state;

     
  3. 3.

    Occupation of the meta-position by an OH- or OCH3-group in the absence of similar groups at the para-position invariably causes a hyperkinesia.

     

Keywords

Dopamine Apomorphine Similar Group Tentative Conclusion Normal Metabolite 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1965

Authors and Affiliations

  • A. M. Ernst
    • 1
  1. 1.Department of PharmacologyUtrecht State UniversityUtrechtThe Netherlands

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