Abstract
Bilateral intrastriatal microinjections in rat brains of quaternary neuroleptic drugs of the butyrophenone type (haloperidol, benperidol, floropipamide) and the indole type (oxypertine) antagonize amphetamine-induced stereotyped behaviour, with the development of catalepsy. These two behavioural effects are also typical for neuroleptics given subcutaneously. No effect was observed when placebo was injected intrastriatally or when quaternary haloperidol was injected into the thalamus or hippocampus. The neuroleptic effect may be exerted through dopaminergic mechanisms in the corpus striatum.
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Andén, N., Roos, B., Werdinius, B.: Effects of chlorpromazine, haloperidol and reserpine on the levels of phenolic acids in rabbit corpus striatum. Life Sci. 3, 149–158 (1964).
Bobon, J., Janssen, P.: Modern problems of pharmacopsychiatry. Symposium on Neuroleptics, Liege, May 1969. Basel: S. Karger 1970.
Fog, R. L., Pakkenberg, H.: Stereotyped, hyperactive behaviour induced in rats by intrastriatal microinjections of p-hydroxy-amphetamine and dopamine. In preparation (1970b).
Fog, R., Randrup, A., Pakkenberg, H.: Amines in the corpus striatum associated with the effects of both amphetamine and antipsychotic drugs. In: J. J. Lopez Ibor, Ed.) Proceedings of the IV. Congress of Psychiatry, part 4, pp. 2580–2582. Madrid: Excerpta Medica Internat. Congress Ser. No. 150, 1966.
— — —: Neuroleptic action of quaternary chlorpromazine and related drugs injected into various brain areas in rats. Psychopharmacologia (Berl.) 12, 428–432 (1968).
— — —: Lesions in corpus striatum and cortex in rat brains and the effect on pharmacologically induced stereotyped, aggressive and cataleptic behaviour. Psychopharmacologia (Berl.) 18, 346–356 (1970).
- - - Stereotyped hyperactive behaviour induced by sham injections in various brain areas in reserpinized rats. In preparation (1970b).
Fuxe, K., Andén, N.: Studies on central monoamine neurons with special reference to the nigro-neostriatal dopamine neuron system. In: E. Costa, L. Coté and M. Yahr (Eds.): Biochemistry and Pharmacology of the Basal Ganglia, p. 123. New York: Raven Press Inc. 1966.
Janssen, P., Niemegers, C., Schellekens, K.: Is it possible to predict the clinical effects of neuroleptic drugs (major tranquillizers) from animal data ? Arzneimittel-Forsch. (Drug Res). 15, 104–117 (1965).
Munkvad, I., Pakkenberg, H., Randrup, A.: Aminergic systems in basal ganglia associated with stereotyped hyperactive behaviour and catalepsy. Brain, Behav., Evol., pp. 89–100, vol. 1. Basel: S. Karger 1968.
Randrup, A.: Role of brain dopamine in the antipsychotic effect of neuroleptics. Evidence from studies of amphetamine-neuroleptic interaction. Modern problems of pharmacopsychiatry, (neuroleptics). Basel: S. Karger 1970.
—, Munkvad, I.: Biochemical, anatomical and psychological investigations of stereotyped behaviour induced by amphetamines. E. Costa and S. Garattini (Eds.). Symposium on Amphetamines and Related Drugs. Milan 1969. New York: Raven Press Inc. 1970.
Rossum, J. M. van., Boissier, J. R., Janssen, P. A. J., Julou, L., Loewe, D. M., Møller, Nielsen I., Munkvad, I., Randrup, A., Stille, G., Tedesci, D. H.: Pharmacology of neuroleptic drugs. Modern problems of pharmacopsychiatry, (neuroleptics). Basel: S. Karger 1970.
Ungerstedt, U., Butcher, L., Butcher, S., Andén, N.-E., Fuxe, K.: Direct chemical stimulation of dopaminergic mechanisms in the neostriatum of the rat. Brain Res. 14, 461–471 (1969).
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Fog, R., Randrup, A. & Pakkenberg, H. Intrastriatal injection of quaternary butyrophenones and oxypertine: Neuroleptic effect in rats. Psychopharmacologia 19, 224–230 (1971). https://doi.org/10.1007/BF00401938
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DOI: https://doi.org/10.1007/BF00401938