Skip to main content
SpringerLink
Log in

Dynamik von Protein-Strukturen

  • Published:
Naturwissenschaften Aims and scope Submit manuscript

Abstract

This review presents a survey of experimental and theoretical methods capable of providing a many-parameter characterization of internal mobility of protein molecules. Special emphasis is on applications of high-resolution nuclear magnetic resonance for studies of non-crystalline proteins and discussions of possible correlations between protein dynamics and biological functions of proteins.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Blundell, T.L., Johnson, L.N.: Protein Crystallography. London: Academic Press 1976

    Google Scholar 

  2. Schulz, G.E., Schirmer, R.H.: Principles of Protein Structure. Berlin — Heidelberg — New York: Springer 1979

    Google Scholar 

  3. Richardson, J.S.: Adv. Prot. Chem. 34, 167 (1981)

    Google Scholar 

  4. Linderstrøm-Lang, K.: Chem. Soc. Spec. Publ. 2, 1 (1955)

    Google Scholar 

  5. Hvidt, A., Nielsen, S.O.: Adv. Prot. Chem. 21, 287 (1966)

    Google Scholar 

  6. Englander, S.W., et al.: Ann. Rev. Biochem. 41, 903 (1972)

    PubMed  Google Scholar 

  7. Woodward, C.K., Hilton, B.D.: Biophys. J. 32, 561 (1980)

    PubMed  Google Scholar 

  8. Wagner, G., Wüthrich, K.: J. Mol. Biol. 134, 75 (1979)

    PubMed  Google Scholar 

  9. Wagner, G., Wüthrich, K.: ibid. 160, 343 (1982)

    PubMed  Google Scholar 

  10. Kossiakoff, A.A.: Nature 296, 713 (1982)

    PubMed  Google Scholar 

  11. Weber, G.: Biochemistry 11, 864 (1972)

    PubMed  Google Scholar 

  12. Munro, I., et al.: Proc. Nat. Acad. Sci. USA 76, 56 (1979)

    PubMed  Google Scholar 

  13. Peticolas, W.L.: Meth. Enzymol. 61, 425 (1979)

    PubMed  Google Scholar 

  14. Allerhand, A., et al.: J. Am. Chem. Soc. 93, 544 (1971)

    PubMed  Google Scholar 

  15. Richarz, R., et al.: Biochemistry 19, 5189 (1980)

    PubMed  Google Scholar 

  16. Ribeiro, A.A., et al.: J. Am. Chem. Soc. 102, 4040 (1980)

    Google Scholar 

  17. Wagner, G., et al.: Biophys. Struct. Mech. 2, 139 (1976)

    PubMed  Google Scholar 

  18. Campbell, I.D., et al.: FEBS Lett. 70, 96 (1976)

    PubMed  Google Scholar 

  19. Wagner, G.: ibid. 112, 280 (1980)

    PubMed  Google Scholar 

  20. Karplus, M., McCammon, J.A.: C.R.C. Crit. Rev. Biochem. 9, 293 (1981)

    Google Scholar 

  21. Gö, N.: Proc. Japan Acad. 56 B, 414 (1980)

    Google Scholar 

  22. Wüthrich, K., et al.: J. Mol. Biol. 155, 311 (1982)

    PubMed  Google Scholar 

  23. Imoto, T., et al.: Enzymes 7, 665 (1972)

    Google Scholar 

  24. Moult, J., et al.: J. Mol. Biol. 100, 179 (1976)

    PubMed  Google Scholar 

  25. Lipscomb, W.N., et al.: Phil. Trans. Roy. Soc. London B 257, 117 (1970)

    Google Scholar 

  26. Perutz, M.F.: Nature 228, 726 (1970)

    PubMed  Google Scholar 

  27. Huber, R.L.: Trends Biochem. Sci. 4, 271 (1979)

    Google Scholar 

  28. Kuntz, I.D., et al.: Biopolymers 18, 939 (1979)

    Google Scholar 

  29. Wako, H., Scheraga, H.A.: J. Prot. Chem. 1, 5 (1982)

    Google Scholar 

  30. Braun, W., et al.: Biochim. Biophys. Acta 667, 377 (1981)

    PubMed  Google Scholar 

  31. Aue, W.P., et al.: J. Chem. Phys. 64, 2229 (1976)

    Google Scholar 

  32. Nagayama, K., et al.: J. Magn. Reson. 40, 321 (1980)

    Google Scholar 

  33. Jeener, J., et al.: J. Chem. Phys. 71, 4546 (1979)

    Article  Google Scholar 

  34. Anil Kumar, et al.: Biochem. Biophys. Res. Commun. 95, 1 (1980)

    PubMed  Google Scholar 

  35. Anil Kumar, et al.: ibid. 96, 1156 (1980)

    PubMed  Google Scholar 

  36. Wüthrich, K.: NMR in Biological Research: Peptides and Proteins. Amsterdam: North-Holland 1976

    Google Scholar 

  37. Noggle, J.H., Schirmer, R.E.: The Nuclear Overhauser Effect. New York: Academic Press 1971

    Google Scholar 

  38. Billeter, M., et al.: J. Mol. Biol. 155, 321 (1982)

    PubMed  Google Scholar 

  39. Dubs, A., et al.: Biochim. Biophys. Acta 577, 177 (1979)

    PubMed  Google Scholar 

  40. Wagner, G., et al.: Eur. J. Biochem. 114, 375 (1981)

    PubMed  Google Scholar 

  41. Wagner, G., Wüthrich, K.: J. Mol. Biol. 155, 347 (1982)

    PubMed  Google Scholar 

  42. Wider G., et al.: ibid. 155, 367 (1982)

    PubMed  Google Scholar 

  43. Wüthrich, K.: Biopolymers (im Druck)

  44. Debye, P.: Ann. Phys. 43, 49 (1914)

    Google Scholar 

  45. Artymiuk, P.J., et al.: Nature 280, 563 (1979)

    PubMed  Google Scholar 

  46. Frauenfelder, H., et al.: ibid. 280, 558 (1979)

    PubMed  Google Scholar 

  47. Wlodawer, A., Sjölin, L.: Proc. Nat. Acad. Sci. USA 79, 1418 (1982)

    PubMed  Google Scholar 

  48. Deisenhofer, J., Steigemann, W.: Acta Cryst. B31, 238 (1975)

    Google Scholar 

  49. Wagner, G.: Quart. Rev. Biophys. (im Druck)

  50. Wagner, G.: Biochem. Biophys. Res. Commun. 97, 614 (1980)

    PubMed  Google Scholar 

  51. Privalov, P.L.: Adv. Prot. Chem. 33, 167 (1979)

    Google Scholar 

  52. Lumry, R., Rosenberg, A.: Coll. Int. C.N.R.S. L'Eau. Syst. Biol. 246, 55 (1975)

    Google Scholar 

  53. Richards, F.M.: Carlsberg Res. Commun. 44, 47 (1979)

    Google Scholar 

  54. Chothia, C.: private Mitteilung

  55. Wüthrich, K., et al.: Biophys. J. 32, 549 (1980)

    PubMed  Google Scholar 

  56. McCammon, J.A., et al.: Nature 267, 585 (1977)

    PubMed  Google Scholar 

  57. Levy, R.M., et al.: J. Am. Chem. Soc. 94, 2657 (1981)

    Google Scholar 

  58. McCammon, J.A., Karplus, M.: Biopolymers 19, 1375 (1980)

    Google Scholar 

  59. van Gunsteren, W.F., Karplus, M.: Nature 293, 677 (1981)

    PubMed  Google Scholar 

  60. Hartmann, H., et al.: Proc. Nat. Acad. Sci. USA 79, 4967 (1982)

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institut für Molekularbiologie und Biophysik der Eidgenössischen Technischen Hochschule, ETH-Hönggerberg, CH-8093, Zürich

    Gerhard Wagner & Kurt Wüthrich

Authors
  1. Gerhard Wagner
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kurt Wüthrich
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Wir danken dem Schweizerischen Nationalfonds für finanzielle Unterstützung unserer Forschungsarbeiten (Project 3.528.79) und E. Huber für die sorgfältige Reinschrift des Manuskripts und Frau J. Richardson, Duke University, Durham N.C., USA, für die Zeichnung zur Fig. 1.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wagner, G., Wüthrich, K. Dynamik von Protein-Strukturen. Naturwissenschaften 70, 105–114 (1983). https://doi.org/10.1007/BF00401593

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00401593

Search

Navigation