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Effects of bufotenine and p-chlorophenylalanine on stress induced behaviour

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  • Animal Studies
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Abstract

Two experiments were conducted in which it was found that bufotenine attenuated, relative to controls: (1) the manifestation of frustrative behaviour as a function of non-reward in a double runway situation and (2) fear reactions typically observed in an open field test. In both experiments, p-chlorophenylalanine, a serotonin depletor, was used effectively to counteract the behavioural effects of bufotenine. The results were interpreted as being in agreement with the general hypothesis that bufotenine reduces an animal's responsiveness to stimulus events. It was also suggested that the behavioural effects of bufotenine are related to its influence on normal serotonin metabolism.

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Authors and Affiliations

  1. Departments of Psychology and Psychiatric Research, University of Saskatchewan, Saskatoon, Canada

    Gordon Winocur, S. P. Bagchi & Pauline Hubbard

  2. Department of Psychology, Trent University, Peterborough, Ontario, Canada

    Gordon Winocur

Authors
  1. Gordon Winocur
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  2. S. P. Bagchi
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  3. Pauline Hubbard
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Additional information

This research was supported by a National Research Council grant (# APA-287) awarded to the first author and by the Public Health Service, Government of Saskatchewan.

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Winocur, G., Bagchi, S.P. & Hubbard, P. Effects of bufotenine and p-chlorophenylalanine on stress induced behaviour. Psychopharmacologia 22, 100–110 (1971). https://doi.org/10.1007/BF00401472

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  • DOI: https://doi.org/10.1007/BF00401472

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