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Structures of lantibiotics studied by NMR

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Abstract

During the last decade, Nuclear Magnetic Resonance has played an important role in the unravelling of the primary and tertiary structures of lantibiotics. A short overview of these studies, together with typical spatial structures obtained, is presented.

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Abbreviations

Ala S :

D-alanyl moiety of meso-lanthionine

S Ala:

L-alanyl moiety of meso-lanthionine

Abu:

3-methylalanyl moiety of (2S3S,6R)-3-methyllanthionine

Dha:

dehydroalanine

Dhb:

dehydrobutyrine

DPC:

docecylphosphocholine

NMR:

Nuclear Magnetic Resonance

NOE:

Nuclear Overhauser Enhancement

NOESY:

NOE spectroscopy

TOCSY:

Total Correlation Spectroscopy

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Authors and Affiliations

  1. Laboratory of Biophysical Chemistry, NSR Center, University of Nijmegen, Toernooiveld, 6525 ED, Nijmegen, the Netherlands

    Frank J. M. van De Ven

  2. Institute für Organische Chemie, Eberhard-Karls-Universität, Auf der Morgenstell 18, D-72076, Tübingen, Germany

    Günther Jung

Authors
  1. Frank J. M. van De Ven
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  2. Günther Jung
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van De Ven, F.J.M., Jung, G. Structures of lantibiotics studied by NMR. Antonie van Leeuwenhoek 69, 99–107 (1996). https://doi.org/10.1007/BF00399415

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