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Structure Elucidation of Antibiotics by NMR Spectroscopy

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Antibiotics

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1520))

Abstract

Nuclear magnetic resonance (NMR) spectroscopy is a powerful tool for the structure elucidation of antibiotics in solution. Over the past 30 years there have been numerous publications describing the use of NMR to characterize naturally derived or synthetic antibiotics. A large number of one-dimensional (1D) and two-dimensional (2D) NMR methods are available today and the list continues to expand. In this chapter, we will consider the key NMR experiments that provide useful information for compound structure elucidation.

The original version of this chapter was revised. The erratum to this chapter is available at: DOI 10.1007/978-1-4939-6634-9_21

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Acknowledgment

This work was supported by the German Federal Ministry of Education and Research (BMBF; Bundesministerium für Bildung und Forschung).

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Authors and Affiliations

  1. Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine-University, Universitaetsstrasse 1, 40225, Duesseldorf, Germany

    Georgios Daletos, Elena Ancheeva & Peter Proksch

  2. Pharmacognosy Department, Faculty of Pharmacy, King Saud University, Riyadh, Saudi Arabia

    Raha S. Orfali

  3. Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124, Braunschweig, Germany

    Victor Wray

Authors
  1. Georgios Daletos
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  2. Elena Ancheeva
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  3. Raha S. Orfali
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  4. Victor Wray
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  5. Peter Proksch
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Corresponding authors

Correspondence to Georgios Daletos or Peter Proksch .

Editor information

Editors and Affiliations

  1. Interfaculty Institute for Microbiology and Infection Medicine, Microbial Bioactive Compounds, University of Tübingen, Tübingen, Germany

    Peter Sass

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Daletos, G., Ancheeva, E., Orfali, R.S., Wray, V., Proksch, P. (2017). Structure Elucidation of Antibiotics by NMR Spectroscopy. In: Sass, P. (eds) Antibiotics. Methods in Molecular Biology, vol 1520. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6634-9_4

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  • DOI: https://doi.org/10.1007/978-1-4939-6634-9_4

  • Published:

  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-6632-5

  • Online ISBN: 978-1-4939-6634-9

  • eBook Packages: Springer Protocols

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