Summary
Several genetic loci have been implicated in the formation of the peripheral nervous system during Drosophila embryogenesis. As a first step towards understanding the functional interrelationships between these genes, we have searched for dominant interactions between deficiencies for the achaete-scute complex (AS-C), daughterless (da) and six other regions necessary for peripheral neurogenesis in the embryo. We have found that adult flies doubly heterozygous for deletions of AS-C and of da, or of AS-C and a small region on the fourth chromosome, exhibit characteristic bristle defects, suggesting that these genes cooperate to form sense organs both in the embryo and in the adult.
Similar content being viewed by others
References
Akam M (1988) The molecular basis for metameric pattern in the Drosophila embryo. Development 101:1–22
Anderson KV, Nüsslein-Volhard C (1986) Dorsal-group genes of Drosophila. In: Gall JG (ed) Gametogenesis and the early embryo. A R Liss, New York, pp 177–194
Bell AE (1954) A gene in Drosophila melanogaster that produces all male progeny. Genetics 39:958–959
Belote JM, McKeown MB, Andrew DJ, Scott TN, Baker BS (1985) Control of sexual differentiation in Drosophila melanogaster. Cold Spring Harbor Symp Quant Biol 50:605–614
Bodmer R, Jan YN (1987) Morphological differentiation of the embryonic peripheral neurons in Drosophila. Roux's Arch Dev Biol 196:69–77
Bodmer R, Barbel S, Sheperd S, Jack JJ, Jan LY, Jan YN (1987) Transformation of sensory organs by mutations of the cut locus of D. melanogaster. Cell 51:293–307
Botas J, Moscoso del Prado J, Garcia-Bellido A (1982) Gene-dose titration analysis in the search of trans-regulatory genes in Drosophila. EMBO J 1:307–310
Cabrera CV, Martinez-Arias A, Bate M (1987) The expression of three members of the achaete-scute complex correlates with neuroblast segregation in Drosophila. Cell 50:425–433
Campos-Ortega JA, Hartenstein V (1985) The embryonic development of Drosophila melanogaster. Springer, Berlin Heidelberg New York Tokyo
Campuzano S, Balcells L, Villares R, Carramolino L, Garcia Alonso L, Modolell J (1986) Excess of function Hairy-wing mutations caused by gypsy and copia transposable elements inserted within structural genes of the achaete-scute locus of Drosophila. Cell 44:303–312
Caudy M, Grell E, Dambly-Chaudière C, Ghysen A, Jan LY, Jan YN (1988) The maternal sex-determination gene daughterless has zygotic activity necessary for the formation of peripheral neurons in Drosophila. Genes Dev 2:843–852
Cronmiller C, Cline TW (1987) The Drosophila sex determination gene daughterless has different functions in the germ line versus the soma. Cell 48:479–487
Dambly-Chaudière C, Ghysen A (1987) Independent subpatterns of sense organs require independent genes of the achaete-scute complex in Drosophila larvae. Genes Dev 1:297–306
Garcia Alonso L, Garcia-Bellido A (1986) Genetic analysis of Hairy-wing mutations. Wilhelm Roux's Arch 195:259–264
Garcia-Bellido A (1981) The bithorax syntagma. In: Lakovaara S (ed) Advances in genetics, development, and evolution of Drosophila. Plenum press, New York, pp 135–148
Garcia-Bellido A (1986) Genetic analysis of morphogenesis. In: Gustafson JP, Stebbins GL, Ayala FJ (eds), Genetics, development and evolution. Plenum Press, New-York, pp 187–209
Garcia-Bellido A, Moscoso del Prado J (1979) Genetic analysis of maternal information in Drosophila. Nature 278:346–348
Garcia-Bellido A, Santamaria P (1978) Developmental analysis of the achaete-scute system of Drosophila melanogaster. Genetics 88:469–486
Ghysen A, Dambly-Chaudière C, Jan LY, Jan YN (1986) Sensory neurons and peripheral pathways in Drosophila embryos. Wilhelm Roux's Arch 195:281–289
Ghysen A, O'Kane C (1988) Development (in press)
Gottlieb FJ (1964) Genetic control of pattern determination in Drosophila. The action of Hairy-wing. Genetics 49:739–760
Homyk T, Emerson CP (1988) Functional interactions between unlinked muscle genes within haploinsufficient regions of the Drosophila genome. Genetics 119:105–121
Jan YN, Bodmer R, Ghysen A, Dambly-Chaudière C, Jan LY (1987) Mutations affecting the peripheral nervous system in Drosophila embryos. In: Law JH (ed) Molecular Entomology. A R Liss, New York, pp 45–56
Lewis EB (1978) A gene complex controlling segmentation in Drosophila. Nature 276:565–570
Nüsslein-Volhard C, Wieschaus E (1980) Mutation affecting segment number and polarity in Drosophila. Nature 287:795–801
Romani S, Campuzano S, Modolell J (1987) The achaete-scute complex is expressed in neurogenic regions of Drosophila embryos. EMBO J 6:2085–2091
Scott MP, O'Farrell PH (1986) Spatial programming of gene expression in early Drosophila embryogenesis. Annu Rev Cell Biol 2:49–80
Tricoire H (1988) Dominant maternal interactions with Drosophila segmentation genes. Roux's Arch Dev Biol 197:115–123
Villares R, Cabrera CV (1987) The achaete-scute gene complex of D. melanogaster: conserved domains in a subset of genes required for neurogenesis and their homology to myc. Cell 50:415–424
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Dambly-Chaudière, C., Ghysen, A., Jan, L.Y. et al. The determination of sense organs in Drosophila: interaction of scute with daughterless . Roux's Arch Dev Biol 197, 419–423 (1988). https://doi.org/10.1007/BF00398993
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00398993