Abstract
To find out whether immunoglobulins are able to recognize foreign antigens in the context of syngeneic MHC determinants, an effort was made to trigger the production of MHC-restricted antibodies by syngeneic Sendai virus (SV)-infected cells using the spleen-fragment culture technique. Antibodies were found that mimicked MHC-restricted antibodies by recognizing MHC + SV better than MHC alone. However, the binding was not specific for SV and also occurred on mitogen-stimulated (SV−) or influenza virus-infected cells. We describe the production of H-2 class I-specific lymphocytotoxic antibodies by primary B cells responding to syngeneic SV-infected cells. No viral-specific, H-2-restricted antibodies were found.
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Kievits, F., Boerenkamp, W.J. & Ivanyi, P. Immunization with syngeneic Sendai virus-infected cells induce no MHC-restricted antibodies but antibodies specific for H-2 class I determinants. Immunogenetics 29, 108–111 (1989). https://doi.org/10.1007/BF00395858
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DOI: https://doi.org/10.1007/BF00395858