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The enhancing effect of cell-wall aggressin on the virulence of Staphylococcus aureus in normal and irradiated mice and in man

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Abstract

Mice irradiated with lethal doses of total body X-irradiation are very susceptible to Staphylococcus aureus. A difference in virulence between a “mouse-virulent” strain and a “mouse-non-virulent” strain which lacks cell-wall aggressin could nevertheless be demonstrated. The virulence of the “mouse-non-virulent” strain could be increased by adding a cell-wall preparation with aggressin-activity (DOCR) from a “mouse-virulent” strain to the inoculum. When injected together with a dose of bacteria lower than the minimum pus-forming dose a lesion-enhancing effect of DOCR from a “mouse-virulent” strain was also demonstrated in man.

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References

  • Agarwal, D. S. 1967a. Subcutaneous staphylococcal infection in mice. I. The role of cotton dust in enhancing infection.—Brit. J. Exp. Pathol. 48: 436–449.

    Google Scholar 

  • Agarwal, D. S. 1967b. Subcutaneous staphylococcal infection in mice. II. The inflammatory response to different strains of staphylococci and micrococci.—Brit. J. Exp. Pathol. 48: 468–482.

    Google Scholar 

  • Bond, V. P., Fliedner, T. M. and Archambeau, J. P. 1965. Mammalian irradiation lethality. A disturbance in cellular kinetics.—Academic Press, New York and London.

    Google Scholar 

  • Elek, S. D. and Conen, P. E. 1957. The virulence of Staphylococcus pyogenes for man. A study of the problems of wound infection.—Brit. J. Exp. Pathol. 38: 573–586.

    Google Scholar 

  • Fisher, S. and Robson, J. E. 1963. Experimental staphylococcal infection of the subcutaneous tissue of the mouse. I. Bacterial population changes in relation to tissue response.—J. Infec. Dis. 113: 204–212.

    Google Scholar 

  • Fisher, S. 1963. Experimental staphylococcal infection of the subcutaneous tissue of the mouse. II. Promotion of the infection with staphylococcal cells and products.—J. Infec. Dis. 113: 213–218.

    Google Scholar 

  • Gorill, R. H. and McNeil, E. M. 1963. Staphylococcal infection in the mouse. I. The effect of route of infection.—Brit. J. Exp. Pathol. 44: 404–415.

    Google Scholar 

  • Hill, M. J. 1968. A staphylococcal aggressin.—J. Med. Microbiol. 1: 33–43.

    Google Scholar 

  • Hill, M. J. 1969. Protection of mice against infection by Staphylococcus aureus.—J. Med. Microbiol. 2: 1–7.

    Google Scholar 

  • Miles, A. A. and Misra, S. S. 1938. The estimation of the bactericidal power of the blood.—J. Hygiene, Cambridge, 38: 732–749.

    Google Scholar 

  • Noble, W. C. 1965. The production of subcutaneous staphylococcal skin lesions in mice.—Brit. J. Exp. Pathol. 46: 254–262.

    Google Scholar 

  • Van der Vijver, J. C. M., Van Es-Boon, M. M. and Michel, M. F. 1972. Lysogenic conversion in Staphylococcus aureus to leucocidin production.—J. Virol. 10: 318–319.

    Google Scholar 

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Authors and Affiliations

  1. Department of Clinical Microbiology and Antimicrobial Therapy, Medical Faculty, Rotterdam, the Netherlands

    J. C. M. van der Vijver, Mary M. van Es-Boon & M. F. Michel

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  1. J. C. M. van der Vijver
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  2. Mary M. van Es-Boon
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  3. M. F. Michel
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van der Vijver, J.C.M., van Es-Boon, M.M. & Michel, M.F. The enhancing effect of cell-wall aggressin on the virulence of Staphylococcus aureus in normal and irradiated mice and in man. Antonie van Leeuwenhoek 40, 49–56 (1974). https://doi.org/10.1007/BF00394552

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  • DOI: https://doi.org/10.1007/BF00394552

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